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A computational approach to microRNA detection
MAY, Patrick; Bauer, Markus; Köberle, Christian et al.
2006
 

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Keywords :
Bioinformatics; MicroRNA
Abstract :
[en] During the last few years more and more functionalities of RNA have been discovered that were previously thought of being carried out by proteins alone. One of the most striking discoveries was the de tection of microRNAs, a class of noncoding RNAs that play an important role in post-transcriptional gene regulation. Large-scale analyses are needed for the still increasingly growing amount of sequen ce data derived from new experimental technologies. In this paper we present a framework for the detection of the distinctive precursor structure of microRNAS that is based on the well-known Smith-Wat erman algorithm and various filtering steps. We conducted experiments on real genomic data and we found several new putative hits for microRNA precursor structures.
Disciplines :
Computer science
Author, co-author :
MAY, Patrick  ;  Zuse Institute Berlin - ZIB > Computer Science Research
Bauer, Markus
Köberle, Christian
Klau, Gunnar
Language :
English
Title :
A computational approach to microRNA detection
Publication date :
2006
Publisher :
ZIB, Takustr.7, 14195 Berlin, Unknown/unspecified
Report number :
06-44
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since 23 April 2013

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