Abud E M et al 2017 iPSC-derived human microglia-like cells to study neurological diseases Neuron 94 278 10.1016/J.NEURON.2017.03.042
Adami C Bianchi R Pula G Donato R 2004 S100B-stimulated NO production by BV-2 microglia is independent of RAGE transducing activity but dependent on RAGE extracellular domain Biochim. Biophys. Acta 1742 169 77 169-77 10.1016/J.BBAMCR.2004.09.008
Aizawa T Haga S Yoshikawa K 1991 Neural differentiation-associated generation of microglia-like phagocytes in murine embryonal carcinoma cell line Dev. Brain Res. 59 89 97 89-97 10.1016/0165-3806(91)90033-F
Ao Z et al 2021 Tubular human brain organoids to model microglia-mediated neuroinflammation Lab Chip 21 2751 10.1039/D1LC00030F
Arnò B et al 2014 Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex Nat. Commun. 5 1 13 1-13 10.1038/ncomms6611
Badanjak K et al 2021 ‘iPSC-derived microglia as a model to study inflammation in idiopathic Parkinson’s disease’, frontiers in cell and developmental biology Front. Cell Dev. Biol. 9 1 11 1-11 10.3389/FCELL.2021.740758
Bejoy J Yuan X Song L Hua T Jeske R Sart S Sang Q-X A Li Y 2019 Genomics analysis of metabolic pathways of human stem cell-derived microglia-like cells and the integrated cortical spheroids Stem Cells Int. 2019 1 21 1-21 10.1155/2019/2382534
Bennett M L et al 2016 New tools for studying microglia in the mouse and human CNS Proc. Natl Acad. Sci. USA 113 E1738 46 E1738-46 10.1073/PNAS.1525528113/-/DCSUPPLEMENTAL
Birey F et al 2017 Assembly of functionally integrated human forebrain spheroids Nature 545 54 59 54-59 10.1038/nature22330
Blinzinger K Kreutzberg G 1968 Displacement of synaptic terminals from regenerating motoneurons by microglial cells Z. Zellforsch Mikrosk. Anat. 85 145 57 145-57 10.1007/BF00325030
Block M L Zecca L Hong J-S 2007 Microglia-mediated neurotoxicity: uncovering the molecular mechanisms Nat. Rev. Neurosci. 8 57 69 57-69 10.1038/nrn2038
Bohlen C J et al 2017 Diverse requirements for microglial survival, specification, and function revealed by defined-medium cultures Neuron 94 759 10.1016/J.NEURON.2017.04.043
Caddeo S Boffito M Sartori S 2017 Tissue engineering approaches in the design of healthy and pathological in vitro tissue models Front. Bioeng. Biotechnol. 5 1 22 1-22 10.3389/FBIOE.2017.00040
Cakir B et al 2022 Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids Nat. Commun. 13 1 15 1-15 10.1038/S41467-022-28043-Y
Castaño A Herrera A J Cano J Machado A 1998 Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system J. Neurochem. 70 1584 92 1584-92 10.1046/J.1471-4159.1998.70041584.X
Chan W Y Kohsaka S Rezaie P 2007 The origin and cell lineage of microglia—new concepts Brain Res. Rev. 53 344 54 344-54 10.1016/J.BRAINRESREV.2006.11.002
Cheadle L et al 2020 Sensory experience engages microglia to shape neural connectivity through a non-phagocytic mechanism Neuron 108 451 10.1016/J.NEURON.2020.08.002
Chiavari M et al 2019 Pro-inflammatory activation of a new immortalized human microglia cell line Brain Sci. 9 1 12 1-12 10.3390/BRAINSCI9050111
Couch Y et al 2011 The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation J. Neuroinflammation 8 1 14 1-14 10.1186/1742-2094-8-166/FIGURES/8
Cross A K Nicola Woodroofe M 1999 Chemokines induce migration and changes in actin polymerization in adult rat brain microglia and a human fetal microglial cell line in vitro J. Neurosci. Res. 55 17 23 17-23 10.1002/(SICI)1097-4547(19990101)55:1<17::AID-JNR3>3.0.CO;2-J
Cserép C et al 2020 Microglia monitor and protect neuronal function through specialized somatic purinergic junctions Science 367 528 237 528-237 10.1126/SCIENCE.AAX6752
Członkowska A Kohutnicka M Kurkowska-Jastrzębska I Członkowski A 1996 Microglial reaction in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induced Parkinson’s disease mice model Neurodegeneration 5 137 43 137-43 10.1006/NEUR.1996.0020
Diaz-Aparicio I et al 2020 Microglia actively remodel adult hippocampal neurogenesis through the phagocytosis secretome J. Neurosci. 40 1453 82 1453-82 10.1523/JNEUROSCI.0993-19.2019
Douvaras P et al 2017 Directed differentiation of human pluripotent stem cells to microglia Stem Cell Reports. Elsevier 8 1516 24 1516-24 10.1016/j.stemcr.2017.04.023
Eyo U B Mo M Yi M-H Murugan M Liu J Yarlagadda R Margolis D J Xu P Wu L-J 2018 P2Y12R-dependent translocation mechanisms gate the changing microglial landscape Cell Rep. 23 959 66 959-66 10.1016/J.CELREP.2018.04.001/ATTACHMENT/5B347F36-F72D-419C-99BA-E430F6644260/MMC5.MP4
Fagerlund I et al 2021 Microglia-like cells promote neuronal functions in cerebral organoids Cells 11 1 23 1-23 10.3390/CELLS11010124
Fillebeen C Ruchoux -M-M Mitchell V Vincent S Benaı̈ssa M Pierce A 2001 Lactoferrin is synthesized by activated microglia in the human substantia nigra and its synthesis by the human microglial CHME cell line is upregulated by tumor necrosis factor alpha or 1-methyl-4-phenylpyridinium treatment Brain Res. Mol. Brain Res. 96 103 13 103-13 10.1016/S0169-328X(01)00216-9
Gabriel E et al 2021 Human brain organoids assemble functionally integrated bilateral optic vesicles Cell Stem Cell 28 1740 57 1740-57 10.1016/J.STEM.2021.07.010
Garcia-Mesa Y Jay T R Checkley M A Luttge B Dobrowolski C Valadkhan S Landreth G E Karn J Alvarez-Carbonell D 2017 Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system J. Neurovirol. 23 47 10.1007/S13365-016-0499-3
Ginhoux F et al 2010 Fate mapping analysis reveals that adult microglia derive from primitive macrophages Science 330 841 5 841-5 10.1126/science.1194637
Ginhoux F Lim S Hoeffel G Low D Huber T 2013 Origin and differentiation of microglia Front. Cell Neurosci. 7 1 14 1-14 10.3389/fncel.2013.00045
Giulian D 1987 Ameboid microglia as effectors of inflammation in the central nervous system J. Neurosci. Res. 18 155 71 155-71 10.1002/JNR.490180123
Giulian D Baker T J Shih L C Lachman L B 1986 Interleukin 1 of the central nervous system is produced by ameboid microglia J. Exp. Med. 164 594 604 594-604 10.1084/JEM.164.2.594
Gjorevski N Ranga A Lutolf M P 2014 Bioengineering approaches to guide stem cell-based organogenesis Development 141 1794 804 1794-804 10.1242/dev.101048
Gomez-Giro G et al 2019 Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis Acta Neuropathol. Commun. 7 1 19 1-19 10.1186/s40478-019-0871-7
Goshi N et al 2020 A primary neural cell culture model to study neuron, astrocyte, and microglia interactions in neuroinflammation J. Neuroinflammation 17 1 16 1-16 10.1186/S12974-020-01819-Z/FIGURES/5
Haenseler W et al 2017 A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response Stem Cell Rep. 8 1727 42 1727-42 10.1016/j.stemcr.2017.05.017
Hasselmann J et al 2019 Development of a chimeric model to study and manipulate human microglia in vivo Neuron 103 1016 33 1016-33 10.1016/J.NEURON.2019.07.002
Hasselmann J Blurton-Jones M 2020 Human iPSC-derived microglia: a growing toolset to study the brain’s innate immune cells Glia 68 721 10.1002/GLIA.23781
Hirsch E C Hunot S 2009 Neuroinflammation in Parkinson’s disease: a target for neuroprotection? Lancet Neurol. 8 382 97 382-97 10.1016/S1474-4422(09)70062-6
Imamura S 1954 Microglia in gliomas Folia Psychiatr. Neurol. Jpn. 8 99 126 99-126 10.1111/J.1440-1819.1954.TB01280.X
Jacob F et al 2021 Building the brain from scratch: engineering region-specific brain organoids from human stem cells to study neural development and disease Curr. Top. Dev. Biol. 142 477 10.1016/BS.CTDB.2020.12.011
Janabi N Peudenier S Héron B Ng K H Tardieu M 1995 Establishment of human microglial cell lines after transfection of primary cultures of embryonic microglial cells with the SV40 large T antigen Neurosci. Lett. 195 105 8 105-8 10.1016/0304-3940(94)11792-H
Jarazo J et al 2021 Parkinson’s disease phenotypes in patient neuronal cultures and brain organoids improved by 2-hydroxypropyl-β-cyclodextrin treatment Mov. Disorders 37 1 16 1-16 10.1002/mds.28810
Jo J et al 2016 Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuromelanin producing neurons Cell Stem Cell 19 248 10.1016/J.STEM.2016.07.005
Kurobane T 1950 Microglia in gliomas; a contribution to the study of microglia Psychiatr. Clin. Neurosci. 4 123 31 123-31 10.1111/J.1440-1819.1950.TB01234.X
Lacaud G Kouskoff V 2017 Hemangioblast, hemogenic endothelium, and primitive versus definitive hematopoiesis Exp. Hematol. 49 19 24 19-24 10.1016/j.exphem.2016.12.009
Lancaster M A et al 2013 Cerebral organoids model human brain development and microcephaly Nature 501 373 9 373-9 10.1038/NATURE12517
Lancaster M A Knoblich J A 2014 Organogenesis in a dish: modeling development and disease using organoid technologies Science 345 283 92 283-92 10.1126/SCIENCE.1247125
Lin Y-T et al 2018 APOE4 causes widespread molecular and cellular alterations associated with Alzheimer’s disease phenotypes in human iPSC-derived brain cell types Neuron 98 1141 54 1141-54 10.1016/J.NEURON.2018.05.008
Lindborg B A et al 2016 Rapid induction of cerebral organoids from human induced pluripotent stem cells using a chemically defined hydrogel and defined cell culture medium Stem Cells Transl. Med. 5 970 9 970-9 10.5966/SCTM.2015-0305
Lopez-Lengowski K et al 2021 Co-culturing microglia and cortical neurons differentiated from human induced pluripotent stem cells J. Vis. Exp. 2021 1 20 1-20 10.3791/62480
Mansour A A Gonçalves J T Bloyd C W Li H Fernandes S Quang D Johnston S Parylak S L Jin X Gage F H 2018 An in vivo model of functional and vascularized human brain organoids Nat. Biotechnol. 36 432 41 432-41 10.1038/nbt.4127
McGeer P L Itagaki S Boyes B E McGeer E G 1988 Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson’s and Alzheimer’s disease brains Neurology 38 1285 91 1285-91 10.1212/WNL.38.8.1285
Menassa D A Gomez-Nicola D 2018 Microglial dynamics during human brain development Front. Immunol. 9 1014 10.3389/FIMMU.2018.01014/BIBTEX
Mittelbronn M Dietz K Schluesener H J Meyermann R 2001 Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude Acta Neuropathol. 101 249 55 249-55 10.1007/s004010000284
Monzel A S et al 2017 Derivation of human midbrain-specific organoids from neuroepithelial stem cells Stem Cell Rep. 8 1144 54 1144-54 10.1016/J.STEMCR.2017.03.010
Moysidou C M Owens R M 2021 Advances in modelling the human microbiome-gut-brain axis in vitro Biochem. Soc. Trans. 49 187 10.1042/BST20200338
Muffat J et al 2016 Efficient derivation of microglia-like cells from human pluripotent stem cells Nat. Med. 22 1358 67 1358-67 10.1038/nm.4189
Nagai A Mishima S Ishida Y Ishikura H Harada T Kobayashi S Kim S U 2005 Immortalized human microglial cell line: phenotypic expression J. Neurosci. Res. 81 342 8 342-8 10.1002/JNR.20478
Nagai A Nakagawa E Hatori K Choi H B McLarnon J G Lee M A Kim S U 2001 Generation and characterization of immortalized human microglial cell lines: expression of cytokines and chemokines Neurobiol. Dis. 8 1057 68 1057-68 10.1006/NBDI.2001.0437
Nimmerjahn A Kirchhoff F Helmchen F 2005 Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo Neuroforum 11 95 96 95-96 10.1515/nf-2005-0304
Ormel P R et al 2018 Microglia innately develop within cerebral organoids Nat. Commun. 9 4167 10.1038/S41467-018-06684-2
Panagiotakopoulou V et al 2020 Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells Nat. Commun. 11 1 17 1-17 10.1038/S41467-020-18755-4
Pandya H et al 2017 Differentiation of human and murine induced pluripotent stem cells to microglia-like cells Nat. Neurosci. 20 753 9 753-9 10.1038/nn.4534
Penfied W 1925 Microglia and the process of phagocytosis in gliomas Am. J. Pathol. 1 77
Popova G et al 2021 Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids Cell Stem Cell 28 2153 66 2153-66 10.1016/J.STEM.2021.08.015
Qian X et al 2016 Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure Cell 165 1238 54 1238-54 10.1016/j.cell.2016.04.032
Réu P et al 2017 The lifespan and turnover of microglia in the human brain Cell Rep. 20 779 84 779-84 10.1016/j.celrep.2017.07.004
Río Hortega P 1919a El “tercer elemento” de los centros nerviosos. I. La microglía en estado normal change ‘Boll Soc. Esp Biol’ to ‘Boll. Soc. Esp. Biol.’ VIII 67 82 67-82
Río Hortega P 1919b El “tercer elemento de los centros nerviosos”. II. Intervención de la microglía en los procesos patológicos (células en bastoncito y cuerpos gránuloadiposos) Boll Soc. Esp Biol VIII 91 103 91-103
Río Hortega P 1919c El “tercer elemento de los centros nerviosos”. III. Naturaleza probable de la microglía Boll Soc. Esp Biol VIII 108 15 108-15
Río Hortega P 1919d El “tercer elemento de los centros nerviosos”. IV. Poder fagocitario y movilidad de la microglía Boll Soc. Esp Biol VIII 154 66 154-66
Roodveldt C Labrador-Garrido A Gonzalez-Rey E Fernandez-Montesinos R Caro M Lachaud C C Waudby C A Delgado M Dobson C M Pozo D 2010 Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson’s disease-linked mutants PLoS One 5 e13481 10.1371/JOURNAL.PONE.0013481
Sabate‐Soler S et al 2022 Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality Glia 70 1267 88 1267-88 10.1002/GLIA.24167
Sawada M et al 1989 Production of tumor necrosis factor-alpha by microglia and astrocytes in culture Brain Res. 491 394 7 394-7 10.1016/0006-8993(89)90078-4
Sawada M et al 1990 Activation and proliferation of the isolated microglia by colony stimulating factor-1 and possible involvement of protein kinase C Brain Res. 509 119 24 119-24 10.1016/0006-8993(90)90317-5
Schmidt S I et al 2021 Microglia-secreted factors enhance dopaminergic differentiation of tissue- and iPSC-derived human neural stem cells Stem Cell Rep. 16 281 10.1016/J.STEMCR.2020.12.011
Scott‐Hewitt N et al 2020 Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia Eur. Mol. Biol. Organ. 39 1 20 1-20 10.15252/embj.2020105380
Sierra A de Castro F Del Río-hortega J Rafael Iglesias-Rozas J Garrosa M Kettenmann H 2016 The “big-bang” for modern glial biology: translation and comments on Pío del Río-Hortega 1919 series of papers on microglia Glia 64 1801 40 1801-40 10.1002/glia.23046
Smits L M et al 2019 Modeling Parkinson’s disease in midbrain-like organoids npj Parkinson’s Dis. 5 1 8 1-8 10.1038/s41531-019-0078-4
Song L et al 2019 Functionalization of brain region-specific spheroids with isogenic microglia-like cells Sci. Rep. 9 1 18 1-18 10.1038/S41598-019-47444-6
Svoboda D S et al 2019 Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain Proc. Natl Acad. Sci. USA 116 25293 303 25293-303 10.1073/PNAS.1913541116/-/DCSUPPLEMENTAL
Takahashi K et al 2007 Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 131 861 72 861-72 10.1016/J.CELL.2007.11.019/ATTACHMENT/ACC16DB6-8022-4ED1-9B4E-D9ED81E29993/MMC8.MPG
Takahashi K Yamanaka S 2006 Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 663 76 663-76 10.1016/J.CELL.2006.07.024
Takata K et al 2017 Induced-pluripotent-stem-cell-derived primitive macrophages provide a platform for modeling tissue-resident macrophage differentiation and function Immunity 47 183 98.e6 183-98.e6 10.1016/j.immuni.2017.06.017
Tansey M G Goldberg M S 2010 Neuroinflammation in Parkinson’s disease: its role in neuronal death and implications for therapeutic intervention Neurobiol. Dis. 37 510 10.1016/J.NBD.2009.11.004
Tavian M Péault B 2005 Embryonic development of the human hematopoietic system Int. J. Dev. Biol. 49 243 50 243-50 10.1387/IJDB.041957MT
Tremblay M É 2012 The role of microglia at synapses in the healthy CNS: novel insights from recent imaging studies Neuron Glia Biol. 7 67 76 67-76 10.1017/S1740925X12000038
Troncoso-Escudero P Parra A Nassif M Vidal R L 2018 Outside in: unraveling the role of neuroinflammation in the progression of Parkinson’s disease Front. Neurol. 9 860 10.3389/FNEUR.2018.00860/BIBTEX
Tu D et al 2019 The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration J. Neuroinflammation 16 1 17 1-17 10.1186/s12974-019-1659-1
Wake H Moorhouse A J Jinno S Kohsaka S Nabekura J 2009 Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals J. Neurosci. 29 3974 80 3974-80 10.1523/JNEUROSCI.4363-08.2009
Walton M R Gibbons H MacGibbon G A Sirimanne E Saura J Gluckman P D Dragunow M 2000 PU.1 expression in microglia J. Neuroimmunol. 104 109 15 109-15 10.1016/S0165-5728(99)00262-3
Wilgenburg B van Browne C Vowles J Cowley S A Covas D Tadeu 2013 Efficient, long term production of monocyte-derived macrophages from human pluripotent stem cells under partly-defined and fully-defined conditions PLoS ONE 8 e71098 10.1371/journal.pone.0071098
Witting A Müller P Herrmann A Kettenmann H Nolte C 2000 Phagocytic clearance of apoptotic neurons by microglia/brain macrophages in vitro: involvement of lectin-, integrin-, and phosphatidylserine-mediated recognition J. Neurochem. 75 1060 70 1060-70 10.1046/j.1471-4159.2000.0751060.x
Xu R et al 2020 Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain Nat. Commun. 11 1 16 1-16 10.1038/s41467-020-15411-9
Xu R Boreland A J Li X Erickson C Jin M Atkins C Pang Z P Daniels B P Jiang P 2021 Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology Stem Cell Rep. 16 1923 10.1016/J.STEMCR.2021.06.011