[en] The ApoE-Trem2 pathway links two of the most important genetic risk variants for sporadic Alzheimer's disease. In this issue of Neuron, Gratuze and colleagues(1) report that Trem2 deficiency further aggravates neurodegeneration in tau mutant mice expressing human ApoE4. Together with previous work, this study points to a complex interaction and highlights the need for studying molecular interactions on all human ApoE variants.
Disciplines :
Neurology
Author, co-author :
Heneka, Michael ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
External co-authors :
no
Language :
English
Title :
ApoE4 makes microglia trem(2)bling.
Publication date :
2023
Journal title :
Neuron
ISSN :
1097-4199
Publisher :
Cell Press, Cambridge, United States - Massachusetts
