ApoE4 makes microglia trem(2)bling.

Reference : ApoE4 makes microglia trem(2)bling.


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Neurology
	To cite this reference:	http://hdl.handle.net/10993/54172

Title :	ApoE4 makes microglia trem(2)bling.
Language :	English
Author, co-author :	Heneka, Michael [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Publication date :	2023
Journal title :	Neuron
Volume :	111
Issue/season :	2
Pages :	142-144
Peer reviewed :	Yes
ISSN :	0896-6273
e-ISSN :	1097-4199
Country :	United States
Keywords :	[en] Animals ; Humans ; Mice ; Alzheimer Disease/genetics/metabolism ; Apolipoprotein E4/genetics/metabolism ; Apolipoproteins E/genetics ; Membrane Glycoproteins/genetics/metabolism ; Microglia/metabolism ; Phagocytosis ; Receptors, Immunologic/genetics/metabolism ; Mice, Transgenic
Abstract :	[en] The ApoE-Trem2 pathway links two of the most important genetic risk variants for sporadic Alzheimer's disease. In this issue of Neuron, Gratuze and colleagues(1) report that Trem2 deficiency further aggravates neurodegeneration in tau mutant mice expressing human ApoE4. Together with previous work, this study points to a complex interaction and highlights the need for studying molecular interactions on all human ApoE variants.
Permalink :	http://hdl.handle.net/10993/54172
DOI :	10.1016/j.neuron.2022
Commentary :	Copyright © 2022 Elsevier Inc. All rights reserved.

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