[en] Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper.
Disciplines :
Neurologie
Auteur, co-auteur :
Paolicelli, Rosa C.
Sierra, Amanda
Stevens, Beth
Tremblay, Marie-Eve
Aguzzi, Adriano
Ajami, Bahareh
Amit, Ido
Audinat, Etienne
Bechmann, Ingo
Bennett, Mariko
Bennett, Frederick
Bessis, Alain
Biber, Knut
Bilbo, Staci
Blurton-Jones, Mathew
Boddeke, Erik
Brites, Dora
Brône, Bert
Brown, Guy C.
Butovsky, Oleg
Carson, Monica J.
Castellano, Bernardo
Colonna, Marco
Cowley, Sally A.
Cunningham, Colm
Davalos, Dimitrios
De Jager, Philip L.
de Strooper, Bart
Denes, Adam
Eggen, Bart J. L.
Eyo, Ukpong
Galea, Elena
Garel, Sonia
Ginhoux, Florent
Glass, Christopher K.
Gokce, Ozgun
Gomez-Nicola, Diego
González, Berta
Gordon, Siamon
Graeber, Manuel B.
Greenhalgh, Andrew D.
Gressens, Pierre
Greter, Melanie
Gutmann, David H.
Haass, Christian
HENEKA, Michael ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
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