Alzheimer’s disease; cognition; locus coeruleus; neurodegeneration; neuroinflammation; noradrenaline; norepinephrine
Résumé :
[en] Alzheimer's disease (AD), which is characterized by extracellular accumulation of amyloid-beta peptide and intracellular aggregation of hyperphosphorylated tau, is the most common form of dementia. Memory loss, cognitive decline and disorientation are the ultimate consequences of neuronal death, synapse loss and neuroinflammation in AD. In general, there are many brain regions affected but neuronal loss in the locus coeruleus (LC) is one of the earliest indicators of neurodegeneration in AD. Since the LC is the main source of noradrenaline (NA) in the brain, degeneration of the LC in AD leads to decreased NA levels, causing increased neuroinflammation, enhanced amyloid and tau burden, decreased phagocytosis and impairment in cognition and long-term synaptic plasticity. In this review, we summarized current findings on the locus coeruleus-noradrenaline system and consequences of its dysfunction which is now recognized as an important contributor to AD progression.
Disciplines :
Neurologie
Auteur, co-auteur :
Mercan, Dilek
HENEKA, Michael ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) ; University of Massachusetts Medical School > Division of Infectious Diseases and Immunology
Co-auteurs externes :
yes
Langue du document :
Anglais
Titre :
The Contribution of the Locus Coeruleus-Noradrenaline System Degeneration during the Progression of Alzheimer's Disease.
Date de publication/diffusion :
2022
Titre du périodique :
Biology
eISSN :
2079-7737
Maison d'édition :
Multidisciplinary Digital Publishing Institute (MDPI), Suisse
World Alzheimer Reports Available online: https://www.alz.co.uk/research/world-report (accessed on 20 December 2019)
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Modulating the Locus Coeruleus Function Available online: https://clinicaltrials.gov/ct2/show/NCT04877782 (accessed on 14 November 2022)
The Wandering Nerve: Gateway to Boost Alzheimer’s Disease Related Cognitive Performance (WALLe) Available online: https://clinicaltrials.gov/ct2/show/NCT04908358 (accessed on 14 November 2022)
