The gut microbiome molecular complex in human health and disease

[en] The human gut microbiome produces a functional complex of biomolecules, including nucleic acids, (poly) peptides, structural molecules, and metabolites. This impacts human physiology in multiple ways, especially by triggering inflammatory pathways in disease. At present, much remains to be learned about the identity of key effectors and their causal roles.

Research center :

- Luxembourg Centre for Systems Biomedicine (LCSB): Eco-Systems Biology (Wilmes Group)

Disciplines :

Microbiology

Author, co-author :

WILMES, Paul ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology

Martin-Gallausiaux, Camille; Institut Pasteur, Paris > Evolutionary Biology of the Microbial Cell

OSTASZEWSKI, Marek ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core

AHO, Velma ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology

NOVIKOVA, Polina ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology

LACZNY, Cedric Christian ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology

SCHNEIDER, Jochen ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Medical Translational Research

External co-authors :

yes

Language :

English

Title :

The gut microbiome molecular complex in human health and disease

Publication date :

14 September 2022

Journal title :

Cell Host and Microbe

ISSN :

1931-3128

eISSN :

1934-6069

Publisher :

Cell Press, Cambridge, United States - Massachusetts

Volume :

Issue :

Pages :

1201-1206

Peer reviewed :

Peer Reviewed verified by ORBi

Focus Area :

Systems Biomedicine

Additional URL :

https://www.sciencedirect.com/science/article/pii/S1931312822004152

European Projects :

H2020 - 863664 - ExpoBiome - Deciphering the impact of exposures from the gut microbiome-derived molecular complex in human health and disease

FnR Project :

FNR11333923 - Non-invasive Microbiome-derived Multi-omic Biomarkers For The Early-stage Detection And Stratification Of Parkinson'S Disease, 2016 (01/09/2017-28/02/2021) - Paul Wilmes

Funders :

CE - Commission Européenne [BE]

Available on ORBilu :

since 19 January 2023

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Bibliography

Aho, V.T.E., Ostaszewski, M., Martin-Gallausiaux, C., Laczny, C.C., Schneider, J.G., Wilmes, P., The Expobiome Map. Cell Host Microbe, 30, 2022, 10.1016/j.chom.2022.08.015.
Blander, J.M., Longman, R.S., Iliev, I.D., Sonnenberg, G.F., Artis, D., Regulation of inflammation by microbiota interactions with the host. Nat. Immunol. 18 (2017), 851–860, 10.1038/ni.3780.
De Saedeleer, B., Malabirade, A., Ramiro-Garcia, J., Habier, J., Trezzi, J.-P., Peters, S.L., Daujeumont, A., Halder, R., Jäger, C., Busi, S.B., et al. Systematic characterization of human gut microbiome-secreted molecules by integrated multi-omics. ISME Commun., 1, 2021, 82, 10.1038/s43705-021-00078-0.
Duvallet, C., Gibbons, S.M., Gurry, T., Irizarry, R.A., Alm, E.J., Meta-analysis of gut microbiome studies identifies disease-specific and shared responses. Nat. Commun., 8, 2017, 1784, 10.1038/s41467-017-01973-8.
Hall, J.A., Bouladoux, N., Sun, C.M., Wohlfert, E.A., Blank, R.B., Zhu, Q., Grigg, M.E., Berzofsky, J.A., Belkaid, Y., Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity 29 (2008), 637–649, 10.1016/j.immuni.2008.08.009.
Heintz-Buschart, A., Wilmes, P., Human gut microbiome: Function matters. Trends Microbiol. 26 (2018), 563–574, 10.1016/j.tim.2017.11.002.
Heintz-Buschart, A., May, P., Laczny, C.C., Lebrun, L.A., Bellora, C., Krishna, A., Wampach, L., Schneider, J.G., Hogan, A., de Beaufort, C., Wilmes, P., Integrated multi-omics of the human gut microbiome in a case study of familial type 1 diabetes. Nat. Microbiol., 2, 2016, 16180, 10.1038/nmicrobiol.2016.180.
Heintz-Buschart, A., Pandey, U., Wicke, T., Sixel-Döring, F., Janzen, A., Sittig-Wiegand, E., Trenkwalder, C., Oertel, W.H., Mollenhauer, B., Wilmes, P., The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder. Mov. Disord. 33 (2018), 88–98, 10.1002/mds.27105.
Jansson, J., Willing, B., Lucio, M., Fekete, A., Dicksved, J., Halfvarson, J., Tysk, C., Schmitt-Kopplin, P., Metabolomics reveals metabolic biomarkers of Crohn's disease. PLoS One, 4, 2009, e6386, 10.1371/journal.pone.0006386.
Longo, V.D., Di Tano, M., Mattson, M.P., Guidi, N., Intermittent and periodic fasting, longevity and disease. Nat Aging 1 (2021), 47–59, 10.1038/s43587-020-00013-3.
Miyauchi, E., Shimokawa, C., Steimle, A., Desai, M.S., Ohno, H., The impact of the gut microbiome on extra-intestinal autoimmune diseases. Nat. Rev. Immunol., 2022, 1–15, 10.1038/s41577-022-00727-y.
Rappaport, S.M., Smith, M.T., Environment and disease risks. Science 330 (2010), 460–461, 10.1126/science.1192603.
Romano, S., Savva, G.M., Bedarf, J.R., Charles, I.G., Hildebrand, F., Narbad, A., Meta-analysis of the Parkinson's disease gut microbiome suggests alterations linked to intestinal inflammation. Npj Parkinsons Dis., 7, 2021, 27, 10.1038/s41531-021-00156-z.
Sampson, T.R., Debelius, J.W., Thron, T., Janssen, S., Shastri, G.G., Ilhan, Z.E., Challis, C., Schretter, C.E., Rocha, S., Gradinaru, V., et al. Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease. Cell 167 (2016), 1469–1480.e12, 10.1016/j.cell.2016.11.018.
Scher, J.U., Sczesnak, A., Longman, R.S., Segata, N., Ubeda, C., Bielski, C., Rostron, T., Cerundolo, V., Pamer, E.G., Abramson, S.B., et al. Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife, 2, 2013, e01202, 10.7554/eLife.01202.
Vierbuchen, T., Bang, C., Rosigkeit, H., Schmitz, R.A., Heine, H., The human-associated archaeon Methanosphaera stadtmanae is recognized through its RNA and induces TLR8-dependent NLRP3 inflammasome activation. Front. Immunol., 8, 2017, 1535, 10.3389/fimmu.2017.01535.