Reference : Curvature in Biological Systems: Its quantification, Emergence and Implications Acros...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Multidisciplinary, general & others
Physics and Materials Science
http://hdl.handle.net/10993/52948
Curvature in Biological Systems: Its quantification, Emergence and Implications Across the Scales
English
Schamberger, Barbara []
Roschger, Andreas []
Sengupta, Anupam mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Physics and Materials Science (DPHYMS) >]
Bidan, Cécile M []
Dunlop, John W. C. []
3-Dec-2022
Advanced Materials
Wiley-VCH
Yes
International
0935-9648
1521-4095
Weinheim
Germany
[en] curvature ; biology ; morphogenesis ; mechanotransduction ; biophysics
[en] Surface curvature both emerges from, and influences the behavior of, living objects at length scales ranging from cell membranes to single cells to tissues and organs. The relevance of surface curvature in biology has been supported by numerous recent experimental and theoretical investigations in recent years. In this review, we first give a brief introduction to the key ideas of surface curvature in the context of biological systems and discuss the challenges that arise when measuring surface curvature. Giving an overview of the emergence of curvature in biological systems, its significance at different length scales becomes apparent. On the other hand, summarizing current findings also shows that both single cells and entire cell sheets, tissues or organisms respond to curvature by modulating their shape and their migration behavior. Finally, we address the interplay between the distribution of morphogens or micro-organisms and the emergence of curvature across length scales with examples demonstrating these key mechanistic principles of morphogenesis. Overall, this review highlights that curved interfaces are not merely a passive by-product of the chemical, biological and mechanical processes but that curvature acts also as a signal that co-determines these processes.
Fonds National de la Recherche - FnR
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/10993/52948
10.1002/adma.202206110
https://onlinelibrary.wiley.com/doi/10.1002/adma.202206110
Open Access
FnR ; FNR11572821 > Anupam Sengupta > MBRACE > Biophysics Of Microbial Adaptation To Fluctuations In The Environment > 15/05/2018 > 14/05/2023 > 2017

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