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03 December 2022
Article (Scientific journals)
Curvature in Biological Systems: Its quantification, Emergence and Implications Across the Scales
Schamberger, Barbara; Roschger, Andreas; Sengupta, Anupam et al.
2022In Advanced Materials
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Advanced Materials - 2022 - Schamberger - Curvature in Biological Systems Its quantification Emergence and Implications.pdf
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Keywords :
curvature; biology; morphogenesis; mechanotransduction; biophysics
Abstract :
[en] Surface curvature both emerges from, and influences the behavior of, living objects at length scales ranging from cell membranes to single cells to tissues and organs. The relevance of surface curvature in biology has been supported by numerous recent experimental and theoretical investigations in recent years. In this review, we first give a brief introduction to the key ideas of surface curvature in the context of biological systems and discuss the challenges that arise when measuring surface curvature. Giving an overview of the emergence of curvature in biological systems, its significance at different length scales becomes apparent. On the other hand, summarizing current findings also shows that both single cells and entire cell sheets, tissues or organisms respond to curvature by modulating their shape and their migration behavior. Finally, we address the interplay between the distribution of morphogens or micro-organisms and the emergence of curvature across length scales with examples demonstrating these key mechanistic principles of morphogenesis. Overall, this review highlights that curved interfaces are not merely a passive by-product of the chemical, biological and mechanical processes but that curvature acts also as a signal that co-determines these processes.
Disciplines :
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others
Author, co-author :
Schamberger, Barbara
Roschger, Andreas
Sengupta, Anupam ;  University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Physics and Materials Science (DPHYMS)
Bidan, Cécile M
Dunlop, John W. C.
External co-authors :
Language :
Title :
Curvature in Biological Systems: Its quantification, Emergence and Implications Across the Scales
Publication date :
03 December 2022
Journal title :
Advanced Materials
Publisher :
Wiley-VCH, Weinheim, Germany
Peer reviewed :
Peer Reviewed verified by ORBi
Focus Area :
Physics and Materials Science
FnR Project :
FNR11572821 > Anupam Sengupta > MBRACE > Biophysics Of Microbial Adaptation To Fluctuations In The Environment > 15/05/2018 > 14/05/2023 > 2017
Funders :
FNR - Fonds National de la Recherche


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