Article (Scientific journals)
Microgliosis: a double-edged sword in the control of food intake
Salvi, Juliette; Andreoletti, Pierre; Audinat, Etienne et al.
2022In FEBS Journal
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Keywords :
eating disorders; energy homeostasis; food intake; hypothalamus; inflammation; lipids; Microglia
Abstract :
[en] Maintaining energy balance is essential for survival and health. This physiological function is controlled by the brain, which adapts food intake to energy needs. Indeed, the brain constantly receives a multitude of biological signals that are derived from digested foods or that originate from the gastrointestinal tract, energy stores (liver and adipose tissues) and other metabolically active organs (muscles). These signals, which include circulating nutrients, hormones and neuronal inputs from the periphery, collectively provide information on the overall energy status of the body. In the brain, several neuronal populations can specifically detect these signals. Nutrient-sensing neurons are found in discrete brain areas and are highly enriched in the hypothalamus. In turn, specialized brain circuits coordinate homeostatic responses acting mainly on appetite, peripheral metabolism, activity and arousal. Accumulating evidence shows that hypothalamic microglial cells located at the vicinity of these circuits can influence the brain control of energy balance. However, microglial cells could have opposite effects on energy balance, that is homeostatic or detrimental, and the conditions for this shift are not totally understood yet. One hypothesis relies on the extent of microglial activation, and nutritional lipids can considerably change it.
Disciplines :
Food science
Author, co-author :
Salvi, Juliette;  Université Bourgogne Franche-Comté > Centre des Sciences du Goût et de l'Alimentation
Andreoletti, Pierre;  Université Bourgogne Franche-Comté > Laboratoire Bio-PeroxlL
Audinat, Etienne;  Université de Montpellier > IGF
Balland, Eglantine;  Faculty of Medicine > Department of Nutrition, Dietetics and Food
Ben Fradj, Selma;  Université Côte d'Azur > IPMC
Cherkaoui-Malki, Mustapha;  Université Bourgogne Franche-Comté > Laboratoire Bio-PeroxlL
Heurtaux, Tony ;  University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM)
Lienard, Fabienne;  Université Bourgogne Franche-Comté > CSGA
Nedelec, Emmanuelle;  Université Bourgogne Franche-Comté > CSGA
Rovere, Carole;  Université Côte d'Azur > IPMC
Savary, Stéphane;  Université Bourgogne Franche-Comté > Laboratoire Bio-PeroxlL
Vejux, Anne;  Université Bourgogne Franche-Comté > Laboratoire Bio-PeroxlL
Trompier, Doriane;  Université Bourgogne Franche-Comté > Laboratoire Bio-PeroxlL
Benani, Alexandre;  Université Bourgogne Franche-Comté > CSGA
More authors (4 more) Less
External co-authors :
yes
Language :
English
Title :
Microgliosis: a double-edged sword in the control of food intake
Publication date :
July 2022
Journal title :
FEBS Journal
ISSN :
1742-4658
Publisher :
Blackwell, Oxford, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 20 September 2022

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