Reference : Microgliosis: a double-edged sword in the control of food intake

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Food science
	To cite this reference:	http://hdl.handle.net/10993/52129

Title :	Microgliosis: a double-edged sword in the control of food intake
Language :	English
Author, co-author :	Salvi, Juliette [Université Bourgogne Franche-Comté > Centre des Sciences du Goût et de l'Alimentation]
	Andreoletti, Pierre [Université Bourgogne Franche-Comté > Laboratoire Bio-PeroxlL]
	Audinat, Etienne [Université de Montpellier > IGF]
	Balland, Eglantine [Faculty of Medicine > Department of Nutrition, Dietetics and Food]
	Ben Fradj, Selma [Université Côte d'Azur > IPMC]
	Cherkaoui-Malki, Mustapha [Université Bourgogne Franche-Comté > Laboratoire Bio-PeroxlL]
	Heurtaux, Tony [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
	Lienard, Fabienne [Université Bourgogne Franche-Comté > CSGA]
	Nedelec, Emmanuelle [Université Bourgogne Franche-Comté > CSGA]
	Rovere, Carole [Université Côte d'Azur > IPMC]
	Savary, Stéphane [Université Bourgogne Franche-Comté > Laboratoire Bio-PeroxlL]
	Vejux, Anne [Université Bourgogne Franche-Comté > Laboratoire Bio-PeroxlL]
	Trompier, Doriane [Université Bourgogne Franche-Comté > Laboratoire Bio-PeroxlL]
	Benani, Alexandre [Université Bourgogne Franche-Comté > CSGA]
Publication date :	Jul-2022
Journal title :	FEBS Journal
Publisher :	Blackwell
Peer reviewed :	Yes
Audience :	International
ISSN :	1742-464X
e-ISSN :	1742-4658
City :	Oxford
Country :	United Kingdom
Keywords :	[en] eating disorders ; energy homeostasis ; food intake ; hypothalamus ; inflammation ; lipids ; Microglia
Abstract :	[en] Maintaining energy balance is essential for survival and health. This physiological function is controlled by the brain, which adapts food intake to energy needs. Indeed, the brain constantly receives a multitude of biological signals that are derived from digested foods or that originate from the gastrointestinal tract, energy stores (liver and adipose tissues) and other metabolically active organs (muscles). These signals, which include circulating nutrients, hormones and neuronal inputs from the periphery, collectively provide information on the overall energy status of the body. In the brain, several neuronal populations can specifically detect these signals. Nutrient-sensing neurons are found in discrete brain areas and are highly enriched in the hypothalamus. In turn, specialized brain circuits coordinate homeostatic responses acting mainly on appetite, peripheral metabolism, activity and arousal. Accumulating evidence shows that hypothalamic microglial cells located at the vicinity of these circuits can influence the brain control of energy balance. However, microglial cells could have opposite effects on energy balance, that is homeostatic or detrimental, and the conditions for this shift are not totally understood yet. One hypothesis relies on the extent of microglial activation, and nutritional lipids can considerably change it.
Permalink :	http://hdl.handle.net/10993/52129
DOI :	10.1111/febs.16583

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