Reference : Machine learning applied to higher order functional representations of omics data rev...
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Systems Biomedicine
http://hdl.handle.net/10993/52061
Machine learning applied to higher order functional representations of omics data reveals biological pathways associated with Parkinson‘s Disease
English
[en] Machine learning applied to higher order functional representations of omics data reveals biological pathways associated with Parkinson‘s Disease
Gómez de Lope, Elisa mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Biomedical Data Science >]
Glaab, Enrico mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Biomedical Data Science >]
18-Sep-2022
A0 sized poster
Yes
International
European Conference on Computational Biology - European Student Council Symposium
18/09/2022 - 21/09/2022
European Conference on Computational Biology,
Sitges, Barcelona
Spain
[en] machine learning ; omics data ; Parkinson Disease ; pathways ; Pathifier
[en] Background: Despite the increasing prevalence of Parkinson’s Disease (PD) and research efforts to understand its underlying molecular pathogenesis, early diagnosis of PD remains a challenge. Machine learning analysis of blood-based omics data is a promising non-invasive approach to finding molecular fingerprints associated with PD that may enable an early and accurate diagnosis.

Description: We applied several machine learning classification methods to public omics data from PD case/control studies. We used aggregation statistics and Pathifier’s pathway deregulation scores to generate higher order functional representations of the data such as pathway-level features. The models’ performance and most relevant predictive features were compared with individual feature level predictors.
The resulting diagnostic models from individual features and Pathifier’s pathway deregulation scores achieve significant Area Under the Curve (AUC, a receiver operating characteristic curve) scores for both cross-validation and external testing. Furthermore, we identify plausible biological pathways associated with PD diagnosis.

Conclusions: We have successfully built machine learning models at pathway-level and single-feature level to study blood-based omics data for PD diagnosis. Plausible biological pathway associations were identified. Furthermore, we show that pathway deregulation scores can serve as robust and biologically interpretable predictors for PD.
Luxembourg Centre for Systems Biomedicine (LCSB): Biomedical Data Science (Glaab Group)
Fonds National de la Recherche - FnR
FNR14599012
Researchers ; Professionals ; Students
http://hdl.handle.net/10993/52061
FnR ; FNR14599012 > Enrico Glaab > DIGIPD > Validating Digital Biomarkers For Better Personalized Treatment Of Parkinson’S Disease > 01/05/2021 > 30/04/2024 > 2020

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