Reference : SARS-CoV-2 transmission risk from asymptomatic carriers: Results from a mass screenin...
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/10993/51820
SARS-CoV-2 transmission risk from asymptomatic carriers: Results from a mass screening programme in Luxembourg
English
Wilmes, Paul mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Ecology]
Zimmer, Jacques mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) >]
Schulz, Jasmin [> >]
Glod, Frank [> >]
Veiber, Lisa [> >]
Mombaerts, Laurent mailto [University of Luxembourg > >]
Rodrigues, Bruno [> >]
Aalto, Atte mailto [University of Luxembourg > >]
Pastore, Jessica [> >]
Snoeck, Chantal J. [> >]
Ollert, Markus mailto [University of Luxembourg > >]
Fagherazzi, Guy mailto [University of Luxembourg > >]
Mossong, Joel mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) >]
Goncalves, Jorge mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Control]
Skupin, Alexander mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Integrative Cell Signalling]
Nehrbass, Ulf mailto [University of Luxembourg > >]
2021
The Lancet Regional Health. Europe
Elsevier
4
100056
Yes (verified by ORBilu)
International
2666-7762
Oxford
United Kingdom
[en] Asymptomatic ; Contact tracing ; COVID-19 ; Mass screening ; rRT-PCR ; SARS-CoV-2
[en] Background To accompany the lifting of COVID-19 lockdown measures, Luxembourg implemented a mass screening (MS) programme. The first phase coincided with an early summer epidemic wave in 2020. Methods rRT-PCR-based screening for SARS-CoV-2 was performed by pooling of samples. The infrastructure allowed the testing of the entire resident and cross-border worker populations. The strategy relied on social connectivity within different activity sectors. Invitation frequencies were tactically increased in sectors and regions with higher prevalence. The results were analysed alongside contact tracing data. Findings The voluntary programme covered 49 of the resident and 22 of the cross-border worker populations. It identified 850 index cases with an additional 249 cases from contact tracing. Over-representation was observed in the services, hospitality and construction sectors alongside regional differences. Asymptomatic cases had a significant but lower secondary attack rate when compared to symptomatic individuals. Based on simulations using an agent-based SEIR model, the total number of expected cases would have been 42·9 (90 CI [-0·3, 96·7]) higher without MS. Mandatory participation would have resulted in a further difference of 39·7 [19·6, 59·2]. Interpretation Strategic and tactical MS allows the suppression of epidemic dynamics. Asymptomatic carriers represent a significant risk for transmission. Containment of future outbreaks will depend on early testing in sectors and regions. Higher participation rates must be assured through targeted incentivisation and recurrent invitation. Funding This project was funded by the Luxembourg Ministries of Higher Education and Research, and Health.
http://hdl.handle.net/10993/51820
10.1016/j.lanepe.2021.100056
https://www.sciencedirect.com/science/article/pii/S2666776221000338

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