Reference : Mechanisms to buffer variability in cell regulation motifs close to criticality
E-prints/Working papers : First made available on ORBilu
Physical, chemical, mathematical & earth Sciences : Multidisciplinary, general & others
Systems Biomedicine
http://hdl.handle.net/10993/51806
Mechanisms to buffer variability in cell regulation motifs close to criticality
English
Proverbio, Daniele mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Control >]
Noronha Montanari, Arthur mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Control >]
Skupin, Alexander mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Integrative Cell Signalling >]
Goncalves, Jorge mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Systems Control >]
2022
No
[en] Critical transitions ; Cell development ; Fokker-Planck
[en] Bistable biological regulatory systems need to cope with stochastic noise to fine-tune their function close to bifurcation points. Here, we study stability properties of this regime in generic systems to demonstrate that cooperative interactions buffer system variability, hampering noise-induced regime shifts. Our analysis also shows that, in the considered cooperativity range, impending regime shifts can be generically detected by statistical early warning signals from distributional data.
Our generic framework, based on minimal models, can be used to extract robustness and variability properties of more complex models and empirical data close to criticality.
Luxembourg Centre for Systems Biomedicine (LCSB): Systems Control (Goncalves Group)
Fonds National de la Recherche - FnR
http://hdl.handle.net/10993/51806
FnR ; FNR10907093 > Jorge Gonçalves > CriTICS > Critical Transitions In Complex Systems: From Theory To Applications > 01/11/2016 > 30/04/2023 > 2015

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