Article (Scientific journals)
Retrograde Procedural Memory in Parkinson’s Disease: A Cross-Sectional, Case-Control Study
Pauly, Laure; Pauly, Claire; Hansen, Maxime et al.
2022In Journal of Parkinson's Disease
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Keywords :
Parkinson's disease; neurodegenerative disorder; cognitive impairment; memory; habits; neuropsychology
Abstract :
[en] Background: The analysis of the procedural memory is particularly relevant in neurodegenerative disorders like Parkinson’s disease, due to the central role of the basal ganglia in procedural memory. It has been shown that anterograde procedural memory, the ability to learn a new skill, is impaired in Parkinson’s disease. However, retrograde procedural memory, the long-term retention and execution of skills learned in earlier life stages, has not yet been systematically investigated in Parkinson’s disease. Objective: This study aims to investigate retrograde procedural memory in people with Parkinson’s disease.We hypothesized that retrograde procedural memory is impaired in people with Parkinson’s disease compared to an age- and gender-matched control group. Methods: First, we developed the CUPRO evaluation system, an extended evaluation system based on the Cube Copying Test, to distinguish the cube copying procedure, representing functioning of retrograde procedural memory, and the final result, representing the visuo-constructive abilities. Development of the evaluation system included tests of discriminant validity. Results: Comparing people with typical Parkinson’s disease (n = 201) with age- and gender-matched control subjects (n = 201), we identified cube copying performance to be significantly impaired in people with Parkinson’s disease (p = 0.008) No significant correlation was observed between retrograde procedural memory and disease duration. Conclusion: We demonstrated lower cube copying performance in people with Parkinson’s disease compared to control subjects, which suggests an impaired functioning of retrograde procedural memory in Parkinson’s disease.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Pauly, Laure ;  Luxembourg Institute of Health - LIH > Transversal Translational Medicine ; University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Pauly, Claire ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience ; Centre Hospitalier de Luxembourg > Department of Neurology
Hansen, Maxime ;  Luxembourg Institute of Health - LIH > Transversal Translational Medicine ; Centre Hospitalier de Luxembourg > Departement of Neurology
Schröder, Valerie ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience ; Centre Hospitalier de Luxembourg > Department of Neurology
Rauschenberger, Armin ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Biomedical Data Science
Leist, Anja  ;  University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Social Sciences (DSOC)
Krüger, Rejko ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience ; Luxembourg Institute of Health - LIH > Transversal translational Medicine ; Centre Hospitalier de Luxembourg > Department of Neurology
External co-authors :
no
Language :
English
Title :
Retrograde Procedural Memory in Parkinson’s Disease: A Cross-Sectional, Case-Control Study
Alternative titles :
[en] Procedural Memory in Parkinson's Disease
Publication date :
17 March 2022
Journal title :
Journal of Parkinson's Disease
ISSN :
1877-718X
Publisher :
IOS Press, Netherlands
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 08 July 2022

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