Anti-seizure activity of African medicinal plants: The identification of bioactive alkaloids from the stem bark of Rauvolfia caffra using an in vivo zebrafish model

Chipiti, Talent; Viljoen M., Alvaro; Cordero Maldonado, Maria Lorena; Veale G L, Clinton; Van Heerden, Fanie; Sandasi, Maxleene; Chen, Weiyang; Crawford, Alexander; Enslin, Gill

doi:10.1016/j.jep.2021.114282

Reference : Anti-seizure activity of African medicinal plants: The identification of bioactive al...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Multidisciplinary, general & others
	Focus Areas :	Systems Biomedicine
	To cite this reference:	http://hdl.handle.net/10993/50272

Title :	Anti-seizure activity of African medicinal plants: The identification of bioactive alkaloids from the stem bark of Rauvolfia caffra using an in vivo zebrafish model
Language :	English
Author, co-author :	Chipiti, Talent [Tshwane University of Technology > Department of Pharmaceutical Sciences]
	Viljoen M., Alvaro [Tshwane University of Technology > Department of Pharmaceutical Sciences]
	Cordero Maldonado, Maria Lorena [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Scientific Central Services >]
	Veale G L, Clinton [University of KwaZulu-Natal > School of Chemistry and Physics]
	Van Heerden, Fanie [University of KwaZulu-Natal > School of Chemistry and Physics]
	Sandasi, Maxleene [Tshwane University of Technology > Department of Pharmaceutical Sciences]
	Chen, Weiyang [Tshwane University of Technology > Department of Pharmaceutical Sciences]
	Crawford, Alexander [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
	Enslin, Gill [Tshwane University of Technology > Department of Pharmaceutical Sciences]
Publication date :	Oct-2021
Journal title :	Journal of Ethnopharmacology
Publisher :	Elsevier
Volume :	28
Issue/season :	279
Peer reviewed :	Yes (verified by ORBi^lu)
Audience :	International
ISSN :	0378-8741
e-ISSN :	1872-7573
City :	Limerick
Country :	Switzerland
Abstract :	[en] Epilepsy is one of the major chronic diseases that does not have a cure to date. Adverse drug reactions have been reported from the use of available anti-epileptic drugs (AEDs) which are also effective in only two-thirds of the patients. Accordingly, the identification of scaffolds with promising anti-seizure activity remains an important first step towards the development of new anti-epileptic therapies, with improved efficacy and reduced adverse effects. Herbal medicines are widely used in developing countries, including in the treatment of epilepsy but with little scientific evidence to validate this use. In the search for new epilepsy treatment options, the zebrafish has emerged as a chemoconvulsant-based model for epilepsy, mainly because of the many advantages that zebrafish larvae offer making them highly suitable for high-throughput drug screening.
Target :	Researchers ; Professionals ; Students ; General public
Permalink :	http://hdl.handle.net/10993/50272
DOI :	10.1016/j.jep.2021.114282

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