Anti-seizure activity of African medicinal plants: The identification of bioactive alkaloids from the stem bark of Rauvolfia caffra using an in vivo zebrafish model
Chipiti, Talent; Viljoen M., Alvaro; CORDERO MALDONADO, Maria Lorenaet al.
[en] Epilepsy is one of the major chronic diseases that does not have a cure to date. Adverse drug reactions have been reported from the use of available anti-epileptic drugs (AEDs) which are also effective in only two-thirds of the patients. Accordingly, the identification of scaffolds with promising anti-seizure activity remains an important first step towards the development of new anti-epileptic therapies, with improved efficacy and reduced adverse effects. Herbal medicines are widely used in developing countries, including in the treatment of epilepsy but with little scientific evidence to validate this use. In the search for new epilepsy treatment options, the zebrafish has emerged as a chemoconvulsant-based model for epilepsy, mainly because of the many advantages that zebrafish larvae offer making them highly suitable for high-throughput drug screening.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Chipiti, Talent; Tshwane University of Technology > Department of Pharmaceutical Sciences
Viljoen M., Alvaro; Tshwane University of Technology > Department of Pharmaceutical Sciences
CORDERO MALDONADO, Maria Lorena ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Scientific Central Services
Veale G L, Clinton; University of KwaZulu-Natal > School of Chemistry and Physics
Van Heerden, Fanie; University of KwaZulu-Natal > School of Chemistry and Physics
Sandasi, Maxleene; Tshwane University of Technology > Department of Pharmaceutical Sciences
Chen, Weiyang; Tshwane University of Technology > Department of Pharmaceutical Sciences
CRAWFORD, Alexander ; University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Enslin, Gill; Tshwane University of Technology > Department of Pharmaceutical Sciences
External co-authors :
yes
Language :
English
Title :
Anti-seizure activity of African medicinal plants: The identification of bioactive alkaloids from the stem bark of Rauvolfia caffra using an in vivo zebrafish model