Reference : Trade-offs in phenotypic noise synchronize emergent topology to actively enhance tran...
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Physics and Materials Science
http://hdl.handle.net/10993/49883
Trade-offs in phenotypic noise synchronize emergent topology to actively enhance transport in microbial environments
English
Dhar, Jayabrata [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Physics and Materials Science (DPHYMS) >]
Thai, Le Phuong Anh [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Physics and Materials Science Research Unit >]
Ghoshal, Arkajyoti [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Physics and Materials Science (DPHYMS) >]
Giomi, Luca []
Sengupta, Anupam mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Physics and Materials Science (DPHYMS) >]
May-2021
No
[en] Active matter ; confluent ; bacterial biofilms ; emergent phenomena ; active transport ; topology
[en] Phenotypic noise underpins homeostasis and fitness of individual cells. Yet, the extent to which noise shapes cell-to-population properties in microbial active matter remains poorly understood. By quantifying variability in confluent \textit{E.coli} strains, we catalogue noise across different phenotypic traits. The noise, measured over different temperatures serving as proxy for cellular activity, spanned more than two orders of magnitude. The maximum noise was associated with the cell geometry and the critical colony area at the onset of mono-to-multilayer transition (MTMT), while the lower bound was set by the critical time of the MTMT. Our results, supported by a hydrodynamic model, suggest that a trade-off between the noise in the cell geometry and the growth rate can lead to the self-regulation of the MTMT timing. The MTMT cascades synchronous emergence of hydrodynamic fields, actively enhancing the micro-environmental transport. Our results highlight how interplay of phenotypic noise triggers emergent deterministic properties, and reveal the role of multifield topology--of the colony structure and hydrodynamics--to insulate confluent systems from the inherent noise associated with natural cell-environment settings.
University of Luxembourg, Department of Physics and Materials Science
Fonds National de la Recherche - FnR ; International Human Frontiers Science Program Organization ; ERC-CoG Grant
ATTRACT Investigator Grant (No. A17/MS/11572821/MBRACE); PRIDE DTU project MICROH (PRIDE17/11823097); AFR Grant (Grant no. 13563560); ERC-CoG (HexaTissue); Netherlands Organization for Scientiļ¬c Research (NWO/OCW)
Researchers ; Professionals ; Students ; General public ; Others
http://hdl.handle.net/10993/49883
https://arxiv.org/abs/2105.00465
https://arxiv.org/abs/2105.00465
FnR ; FNR11572821 > Anupam Sengupta > MBRACE > Biophysics Of Microbial Adaptation To Fluctuations In The Environment > 15/05/2018 > 14/05/2023 > 2017

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