Reference : Genotypic and antigenic characterization of hemagglutinin proteins of African measles...

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/10993/4929

Title :	Genotypic and antigenic characterization of hemagglutinin proteins of African measles virus isolates
Language :	English
Author, co-author :	Truong, A. T. [Department of Virology, University College Hospital Ibadan, Ibadan, Nigeria]
	Kreis, Stephanie [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
	Ammerlaan, W. [LVO, Rijksinstituut V. Volksgezondheid M., Bilthoven, Netherlands]
	Hartter, H. K. [> >]
	Adu, F. [> >]
	Omilabu, S. A. [> >]
	Oyefolu, A. O. [> >]
	Berbers, G. A. M. [> >]
	Muller, Claude [CRP-Santé Luxembourg]
Publication date :	1999
Journal title :	Virus Research
Publisher :	Elsevier Science
Volume :	62
Issue/season :	1
Pages :	89-95
Peer reviewed :	Yes (verified by ORBilu)
ISSN :	0168-1702
City :	Amsterdam
Country :	The Netherlands
Keywords :	[en] Africa; Hemagglutinin; Measles virus; Monoclonal antibodies; Sequence
Abstract :	[en] A comprehensive phylogenetic study based on the hemagglutinin (H) protein of all known African measles virus (MV) isolates is presented. The study includes 64 new H gene sequences from Ghana, Nigeria and South Africa as well as viruses from Zambia and The Gambia for which only incomplete sequencing data were available and that have previously not been genotyped. The results provide further support to the tentative assignment of the Nigerian and Ghanaian viruses to a new genotype B3 within clade B. A distinct geographic distribution pattern emerged with clade B viruses circulating exclusively in African countries north of the equator. All MV strains from southern Africa grouped in clades A and D with the majority of viruses belonging to genotype D4. The viruses considerably differed by their sensitivity to neutralization by monoclonal antibodies (mAb), but three selected antibodies were sufficient to distinguish between African MVs representing four different genotypes. Copyright (C) 1999 Elsevier Science B.V.
Permalink :	http://hdl.handle.net/10993/4929
DOI :	10.1016/S0168-1702(99)00072-6
Other URL :	http://www.scopus.com/inward/record.url?eid=2-s2.0-0032797481&partnerID=40&md5=a0b7b169a0a7f030e8256fe79a1424f9
Commentary :	cited By (since 1996)38 Scopus

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