Article (Scientific journals)
Longitudinal Assessment of Physical Activity, Fitness, Body Composition, Immunological Biomarkers, and Psychological Parameters During the First Year After Diagnosis in Women With Non-Metastatic Breast Cancer: The BEGYN Study Protocol
Zemlin, Cosima; Stuhlert, Caroline; Schleicher, Julia Theresa et al.
2021In Frontiers in Oncology, 11
Peer Reviewed verified by ORBi
 

Files


Full Text
begyn study protocol Publication.pdf
Publisher postprint (3.17 MB)
Request a copy

All documents in ORBilu are protected by a user license.

Send to



Details



Abstract :
[en] Background: Moderate physical activity is associated with an improved prognosis and psychosocial outcome in breast cancer patients. Although exercise and physical activity are associated with multiple physiological and psychological effects, many of the underlying mechanisms remain obscure. The BEGYN study (Influence of physical activity in breast cancer patients on physiological and psychological parameters and on biomarkers) aims at identifying potential associations between the extent of physical activity, fitness, body composition, immunological biomarkers, psycho-emotional parameters, and the course of treatment during the first year after diagnosis of breast cancer. Methods: The prospective observational BEGYN study will include 110 non-metastatic breast cancer patients. The patients will be assessed during a base line visit prior to the initiation of the antineoplastic therapy and after 3, 6, 9 and 12 months. The physical activity will be measured using a fitness tracker and a self-assessment diary during the entire study. Each visit will include the assessment of (i) cardiorespiratory fitness measured by spiroergometry, (ii) body composition, (iii) psycho-emotional parameters (quality of life, mental health, fatigue, depression, distress, anxiety, well-being), and (iv) extensive blood tests including routine laboratory, vitamin D, selenium and immunologically relevant biomarkers (e.g., leukocyte subpopulations and cytokine profiles). Discussion: Whereas most studies investigating the influence of physical activity in breast cancer patients focus on specific activities for three months or less, the BEGYN study will quantify the daily physical activity and cardiorespiratory fitness of breast cancer patients based on objective measurements in the context of the oncological therapy for 12 months after diagnosis. The study will reveal potential associations between exercise, immune status and physical as well as psycho-emotional outcome and the clinical course of the disease. Moreover, complementary therapies such as Vit D and Selenium supplementation and parameters investigating the motivation of the patients are part of the study. Due to this holistic approach, the BEGYN study will guide towards confirmatory studies on the role of physical activity in breast cancer patients to develop individualized counselling regarding the recommended type and extent of exercise.
Disciplines :
Treatment & clinical psychology
Author, co-author :
Zemlin, Cosima
Stuhlert, Caroline
Schleicher, Julia Theresa
Wörmann, Caroline
Altmayer, Laura
Lang, Marina
Scherer, Laura-Sophie
Thul, Ida Clara
Müller, Carolin
Kaiser, Elisabeth
Stutz, Regine
Goedecke-Fritz, Sybille
Ketter, Laura
Zemlin, Michael
Wagenpfeil, Gudrun
STEFFGEN, Georges ;  University of Luxembourg > Faculty of Humanities, Education and Social Sciences (FHSE) > Department of Behavioural and Cognitive Sciences (DBCS)
Solomayer, Erich-Franz
More authors (7 more) Less
External co-authors :
yes
Language :
English
Title :
Longitudinal Assessment of Physical Activity, Fitness, Body Composition, Immunological Biomarkers, and Psychological Parameters During the First Year After Diagnosis in Women With Non-Metastatic Breast Cancer: The BEGYN Study Protocol
Publication date :
19 October 2021
Journal title :
Frontiers in Oncology
ISSN :
2234-943X
Publisher :
Frontiers Media, Lausanne, Switzerland
Volume :
11
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 08 December 2021

Statistics


Number of views
55 (9 by Unilu)
Number of downloads
0 (0 by Unilu)

Scopus citations®
 
8
Scopus citations®
without self-citations
5
OpenCitations
 
2
WoS citations
 
6

Bibliography


Similar publications



Contact ORBilu