Reference : Integration of proteomic and metabolomic profiling as well as metabolic modeling for ...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Integration of proteomic and metabolomic profiling as well as metabolic modeling for the functional analysis of metabolic networks.
May, Patrick mailto [Max Planck Institute for Molecular Plant Physiology > Bioinformatics]
Christian, Nils mailto [Max Planck Institute for Molecular Plant Physiology]
Ebenhoh, Oliver [> >]
Weckwerth, Wolfram [> >]
Walther, Dirk [> >]
Methods in Molecular Biology
Yes (verified by ORBilu)
United States
[en] Cluster Analysis ; Hordeum/metabolism ; Metabolic Networks and Pathways ; Metabolomics/methods ; Models, Biological ; Proteomics/methods ; Seeds/metabolism ; Software ; Time Factors
[en] The integrated analysis of different omics-level data sets is most naturally performed in the context of common process or pathway association. In this chapter, the two basic approaches for a metabolic pathway-centric integration of proteomics and metabolomics data are described: the knowledge-based approach relying on existing metabolic pathway information, and a data-driven approach that aims to deduce functional (pathway) associations directly from the data. Relevant algorithmic approaches for the generation of metabolic networks of model organisms, their functional analysis, database resources, visualization and analysis tools will be described. The use of proteomics data in the process of metabolic network reconstruction will be discussed.

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