Reference : Astrocyte-Neuron Metabolic Crosstalk in Neurodegeneration: A Mitochondrial Perspective.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/48559
Astrocyte-Neuron Metabolic Crosstalk in Neurodegeneration: A Mitochondrial Perspective.
English
Mulica, Patrycja mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Molecular and Functional Neurobiology]
Grünewald, Anne mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Molecular and Functional Neurobiology]
Pereira, Sandro L. [> >]
2021
Frontiers in endocrinology
12
668517
Yes (verified by ORBilu)
1664-2392
1664-2392
[en] Alzheimer’s disease ; Parkinson’s disease ; astrocytes ; metabolism ; neurodegeneration ; neurons
[en] Converging evidence made clear that declining brain energetics contribute to aging and are implicated in the initiation and progression of neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Indeed, both pathologies involve instances of hypometabolism of glucose and oxygen in the brain causing mitochondrial dysfunction, energetic failure and oxidative stress. Importantly, recent evidence suggests that astrocytes, which play a key role in supporting neuronal function and metabolism, might contribute to the development of neurodegenerative diseases. Therefore, exploring how the neuro-supportive role of astrocytes may be impaired in the context of these disorders has great therapeutic potential. In the following, we will discuss some of the so far identified features underlining the astrocyte-neuron metabolic crosstalk. Thereby, special focus will be given to the role of mitochondria. Furthermore, we will report on recent advancements concerning iPSC-derived models used to unravel the metabolic contribution of astrocytes to neuronal demise. Finally, we discuss how mitochondrial dysfunction in astrocytes could contribute to inflammatory signaling in neurodegenerative diseases.
http://hdl.handle.net/10993/48559
10.3389/fendo.2021.668517
Copyright © 2021 Mulica, Grünewald and Pereira.
FnR ; FNR13688526 > Anne Grünewald > CAMeSyn > Contribution Of Astrocyte Metabolism To Synucleinopathy In Parkinson’S Disease. > 01/09/2020 > 31/08/2023 > 2019

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
fendo-12-668517.pdfPublisher postprint1.87 MBView/Open

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.