Reference : Approaches for completing metabolic networks through metabolite damage and repair dis...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/48342
Approaches for completing metabolic networks through metabolite damage and repair discovery
English
Griffith, Corey mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Enzymology and Metabolism >]
Walvekar, Adhish mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Enzymology and Metabolism >]
Linster, Carole mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Enzymology and Metabolism >]
9-Sep-2021
Current Opinion in Systems Biology
Elsevier
28
Yes
International
2452-3100
[en] Metabolites are prone to damage, either via enzymatic side reactions, which collectively form the underground metabolism, or via spontaneous chemical reactions. The resulting non-canonical metabolites that can be toxic, are mended by dedicated “metabolite repair enzymes.” Deficiencies in the latter can cause severe disease in humans, whereas inclusion of repair enzymes in metabolically engineered systems can improve the production yield of value-added chemicals. The metabolite damage and repair loops are typically not yet included in metabolic reconstructions and it is likely that many remain to be discovered. Here, we review strategies and associated challenges for unveiling non-canonical metabolites and metabolite repair enzymes, including systematic approaches based on high-resolution mass spectrometry, metabolome-wide side-activity prediction, as well as high-throughput substrate and phenotypic screens.
Fonds National de la Recherche - FnR ; European Commission - EC
http://hdl.handle.net/10993/48343
also: http://hdl.handle.net/10993/48584
10.1016/j.coisb.2021.100379
FnR ; FNR12661133 > Carole Linster > NAXDE > Cellular Models Of A New Paediatric Neurodegenerative Disorder To Investigate Disease Mechanism, Develop Diagnostic Tools And Test Small Molecule Treatments > 01/05/2019 > 30/04/2022 > 2018

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