Reference : A platform for experimental precision medicine: The extended BXD mouse family.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/48046
A platform for experimental precision medicine: The extended BXD mouse family.
English
Ashbrook, David G. [> >]
Arends, Danny [> >]
Prins, Pjotr [> >]
Mulligan, Megan K. [> >]
Roy, Suheeta [> >]
Williams, Evan mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Gene Expression and Metabolism]
Lutz, Cathleen M. [> >]
Valenzuela, Alicia [> >]
Bohl, Casey J. [> >]
Ingels, Jesse F. [> >]
McCarty, Melinda S. [> >]
Centeno, Arthur G. [> >]
Hager, Reinmar [> >]
Auwerx, Johan [> >]
Lu, Lu [> >]
Williams, Robert W. [> >]
2021
Cell systems
12
3
235-247.e9
Yes
2405-4712
2405-4720
[en] GXE ; complex trait ; gene mapping ; personalized medicine ; power calculation ; recombinant inbred strains ; systems biology ; systems genetics
[en] The challenge of precision medicine is to model complex interactions among DNA variants, phenotypes, development, environments, and treatments. We address this challenge by expanding the BXD family of mice to 140 fully isogenic strains, creating a uniquely powerful model for precision medicine. This family segregates for 6 million common DNA variants-a level that exceeds many human populations. Because each member can be replicated, heritable traits can be mapped with high power and precision. Current BXD phenomes are unsurpassed in coverage and include much omics data and thousands of quantitative traits. BXDs can be extended by a single-generation cross to as many as 19,460 isogenic F1 progeny, and this extended BXD family is an effective platform for testing causal modeling and for predictive validation. BXDs are a unique core resource for the field of experimental precision medicine.
http://hdl.handle.net/10993/48046
Copyright © 2020 Elsevier Inc. All rights reserved.

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