Profil

WILLIAMS Evan

University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Gene Expression and Metabolism

ORCID
0000-0002-9746-376X
Main Referenced Co-authors
Auwerx, Johan (28)
Aebersold, Ruedi (15)
Williams, Robert W. (8)
Jha, Pooja (7)
Lu, Lu (7)
Main Referenced Keywords
Animals (24); Humans (20); Mice (19); Quantitative Trait Loci (11); Male (8);
Main Referenced Disciplines
Genetics & genetic processes (37)
Biochemistry, biophysics & molecular biology (5)
Biotechnology (2)
Life sciences: Multidisciplinary, general & others (1)

Publications (total 45)

The most downloaded
451 downloads
WILLIAMS, E., Wu, Y., Jha, P., Dubuis, S., Blattmann, P., Argmann, C. A., Houten, S. M., Amariuta, T., Wolski, W., Zamboni, N., Aebersold, R., & Auwerx, J. (2016). Systems proteomics of liver mitochondria function. Science, 352 (6291), 0189. doi:10.1126/science.aad0189 https://hdl.handle.net/10993/43154

The most cited

680 citations (Scopus®)

Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-Dit-Felix, A. A., WILLIAMS, E., Jha, P., Lo Sasso, G., Huzard, D., Aebischer, P., Sandi, C., Rinsch, C., & Auwerx, J. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature Medicine, 22 (8), 879-88. doi:10.1038/nm.4132 https://hdl.handle.net/10993/43153

Allayee, H., Farber, C. R., Seldin, M. M., WILLIAMS, E., James, D. E., & Lusis, A. J. (14 November 2023). Systems genetics approaches for understanding complex traits with relevance for human disease. eLife, 12. doi:10.7554/eLife.91004
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Li, X., Morel, J.-D., Benegiamo, G., Poisson, J., Bachmann, A., Rapin, A., Sulc, J., WILLIAMS, E., Perino, A., Schoonjans, K., Bou Sleiman, M., & Auwerx, J. (19 October 2023). Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population. eLife, 12. doi:10.7554/eLife.87569
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Xu, F., Ziebarth, J. D., Goeminne, L. J., Gao, J., WILLIAMS, E., Quarles, L. D., Makowski, L., Cui, Y., Williams, R. W., Auwerx, J., & Lu, L. (September 2023). Gene network based analysis identifies a coexpression module involved in regulating plasma lipids with high-fat diet response. Journal of Nutritional Biochemistry, 119, 109398. doi:10.1016/j.jnutbio.2023.109398
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Li, H., Perino, A., Huang, Q., von Alvensleben, G., Banaei-Esfahani, A., Velazquez-Villegas, L., Gariani, K., Korbelius, M., Bou Sleiman, M., Imbach, J., Sun, Y., Li, X., Bachmann, A., Goeminne, L., Gallart-Ayala, H., WILLIAMS, E., Ivanisevic, J., Auwerx, J., & Schoonjans, K. (04 October 2022). Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis. Cell Metabolism, 34 (10), 1594-1610. doi:10.1016/j.cmet.2022.08.015
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Sharma, V., Fossati, A., Ciuffa, R., Buljan, M., WILLIAMS, E., Chen, Z., Shao, W., Pedrioli, P., Purcell, A., Rodriguez Martinez, M., Song, J., Manica, M., Aebersold, R., & Li, C. (23 July 2022). PCfun: a hybrid computational framework for systematic characterization of protein complex function. Briefings in Bioinformatics, 23 (4), 239. doi:10.1093/bib/bbac239
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Addicks, G., Zhang, H., Ryu, D., Vasam, G., Green, A., Marshall, P., Patel, S., Kang, B., Kim, D., Katsyuba, E., WILLIAMS, E., Renaud, J.-M., Auwerx, J., & Menzies, K. (07 February 2022). GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression. Journal of Cell Biology, 221 (2). doi:10.1083/jcb.202104022
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Morel, J.-D., Sauzéat, L., Goeminne, L., Jha, P., WILLIAMS, E., Houtkooper, R., Auwerx, J., & Balter, V. (01 February 2022). The mouse metallomic landscape of aging and metabolism. Nature Communications, 13 (607). doi:10.1038/s41467-022-28060-x
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WILLIAMS, E., Pfister, N., Roy, S., Statzer, C., Haverty, J., Ingels, J., Bohl, C., Hasan, M., Cuklina, J., Bühlmann, P., Zamboni, N., Lu, L., Ewald, C., Williams, R., & Aebersold, R. (19 January 2022). Multiomic profiling of the liver across diets and age in a diverse mouse population. Cell Systems, 13 (1), 43-57. doi:10.1016/j.cels.2021.09.005
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Roy, S., Bou Sleiman, M., Jha, P., Ingels, J., Chapman, C., McCarty, M., Ziebarth, J., Hook, M., Sun, A., Zhao, W., Huang, J., Neuner, S., Wilmott, L., Shapaker, T., Centeno, A., Ashbrook, D., Mulligan, M., Kaczorowski, C., Makowski, L., ... Williams, R. (2021). Gene-by-environment modulation of lifespan and weight gain in the murine BXD family. Nature Metabolism. doi:10.1038/s42255-021-00449-w
Peer reviewed

Ashbrook, D. G., Arends, D., Prins, P., Mulligan, M. K., Roy, S., WILLIAMS, E., Lutz, C. M., Valenzuela, A., Bohl, C. J., Ingels, J. F., McCarty, M. S., Centeno, A. G., Hager, R., Auwerx, J., Lu, L., & Williams, R. W. (2021). A platform for experimental precision medicine: The extended BXD mouse family. Cell Systems, 12 (3), 235-247.e9. doi:10.1016/j.cels.2020.12.002
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Čuklina, J., Lee, C. H., WILLIAMS, E., Sajic, T., Collins, B. C., Rodríguez Martínez, M., Sharma, V. S., Wendt, F., Goetze, S., Keele, G. R., Wollscheid, B., Aebersold, R., & Pedrioli, P. G. A. (2021). Diagnostics and correction of batch effects in large-scale proteomic studies: a tutorial. Molecular Systems Biology, 17 (8), 10240. doi:10.15252/msb.202110240
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van der Kolk, B. W., Saari, S., Lovric, A., Arif, M., Alvarez, M., Ko, A., Miao, Z., Sahebekhtiari, N., Muniandy, M., Heinonen, S., Oghabian, A., Jokinen, R., Jukarainen, S., Hakkarainen, A., Lundbom, J., Kuula, J., Groop, P.-H., Tukiainen, T., Lundbom, N., ... Pietiläinen, K. H. (2021). Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI. Cell Reports Medicine, 2 (4), 100226. doi:10.1016/j.xcrm.2021.100226
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Pfister, N., WILLIAMS, E., Peters, J., Aebersold, R., & Bühlmann, P. (2021). Stabilizing variable selection and regression. Annals of Applied Statistics, 15 (3). doi:10.1214/21-AOAS1487
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Molenaars, M., Janssens, G. E., WILLIAMS, E., Jongejan, A., Lan, J., Rabot, S., Joly, F., Moerland, P. D., Schomakers, B. V., Lezzerini, M., Liu, Y. J., McCormick, M. A., Kennedy, B. K., van Weeghel, M., van Kampen, A. H. C., Aebersold, R., MacInnes, A. W., & Houtkooper, R. H. (2020). A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways. Cell Metabolism, 31 (3), 549-563.e7. doi:10.1016/j.cmet.2020.01.011
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Liu, Y. J., McIntyre, R. L., Janssens, G. E., WILLIAMS, E., Lan, J., van Weeghel, M., Schomakers, B., van der Veen, H., van der Wel, N. N., Yao, P., Mair, W. B., Aebersold, R., MacInnes, A. W., & Houtkooper, R. H. (2020). Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30. The Journal of cell biology, 219 (6). doi:10.1083/jcb.201907067
Peer reviewed

Rosenberger, G., Heusel, M., Bludau, I., Collins, B. C., Martelli, C., WILLIAMS, E., Xue, P., Liu, Y., Aebersold, R., & Califano, A. (2020). SECAT: Quantifying Protein Complex Dynamics across Cell States by Network-Centric Analysis of SEC-SWATH-MS Profiles. Cell Systems, 11 (6), 589-607.e8. doi:10.1016/j.cels.2020.11.006
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Sandoval-Sierra, J. V., Helbing, A. H. B., WILLIAMS, E., Ashbrook, D. G., Roy, S., Williams, R. W., & Mozhui, K. (2020). Body weight and high-fat diet are associated with epigenetic aging in female members of the BXD murine family. Aging cell, 19 (9), 13207. doi:10.1111/acel.13207
Peer reviewed

Liu, Y., Mi, Y., Mueller, T., Kreibich, S., WILLIAMS, E., Van Drogen, A., Borel, C., Frank, M., Germain, P.-L., Bludau, I., Mehnert, M., Seifert, M., Emmenlauer, M., Sorg, I., Bezrukov, F., Bena, F. S., Zhou, H., Dehio, C., Testa, G., ... Aebersold, R. (2019). Multi-omic measurements of heterogeneity in HeLa cells across laboratories. Nature Biotechnology, 37 (3), 314-322. doi:10.1038/s41587-019-0037-y
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Sajic, T., Ciuffa, R., Lemos, V., Xu, P., Leone, V., Li, C., WILLIAMS, E., Makris, G., Banaei-Esfahani, A., Heikenwalder, M., Schoonjans, K., & Aebersold, R. (2019). A new class of protein biomarkers based on subcellular distribution: application to a mouse liver cancer model. Scientific Reports, 9 (1), 6913. doi:10.1038/s41598-019-43091-z
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Perez-Munoz, M. E., McKnite, A. M., WILLIAMS, E., Auwerx, J., Williams, R. W., Peterson, D. A., & Ciobanu, D. C. (2019). Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population. PLoS ONE, 14 (10), 0224100. doi:10.1371/journal.pone.0224100
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WILLIAMS, E., & Stein, S. (2019). JCAD: from systems genetics identification to the experimental validation of a coronary artery disease risk locus. European Heart Journal, 40 (29), 2409-2412. doi:10.1093/eurheartj/ehz370
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Leandro, J., Violante, S., Argmann, C. A., Hagen, J., Dodatko, T., Bender, A., Zhang, W., WILLIAMS, E., Bachmann, A. M., Auwerx, J., Yu, C., & Houten, S. M. (2019). Mild inborn errors of metabolism in commonly used inbred mouse strains. Molecular Genetics and Metabolism, 126 (4), 388-396. doi:10.1016/j.ymgme.2019.01.021
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WILLIAMS, E., Wu, Y., Wolski, W., Kim, J. Y., Lan, J., Hasan, M., Halter, C., Jha, P., Ryu, D., Auwerx, J., & Aebersold, R. (2018). Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population. Molecular and Cellular Proteomics, 17 (9), 1766-1777. doi:10.1074/mcp.RA118.000554
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Jha, P., McDevitt, M. T., Halilbasic, E., WILLIAMS, E., Quiros, P. M., Gariani, K., Sleiman, M. B., Gupta, R., Ulbrich, A., Jochem, A., Coon, J. J., Trauner, M., Pagliarini, D. J., & Auwerx, J. (2018). Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes. Cell systems, 6 (6), 709-721.e6. doi:10.1016/j.cels.2018.05.009
Peer reviewed

Sajic, T., Liu, Y., Arvaniti, E., Surinova, S., WILLIAMS, E., Schiess, R., Huttenhain, R., Sethi, A., Pan, S., Brentnall, T. A., Chen, R., Blattmann, P., Friedrich, B., Nimeus, E., Malander, S., Omlin, A., Gillessen, S., Claassen, M., & Aebersold, R. (2018). Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS. Cell Reports, 23 (9), 2819-2831.e5. doi:10.1016/j.celrep.2018.04.114
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Jha, P., McDevitt, M. T., Gupta, R., Quiros, P. M., WILLIAMS, E., Gariani, K., Sleiman, M. B., Diserens, L., Jochem, A., Ulbrich, A., Coon, J. J., Auwerx, J., & Pagliarini, D. J. (2018). Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species. Cell systems, 6 (6), 722-733.e6. doi:10.1016/j.cels.2018.05.016
Peer reviewed

Hook, M., Roy, S., WILLIAMS, E., Bou Sleiman, M., Mozhui, K., Nelson, J. F., Lu, L., Auwerx, J., & Williams, R. W. (2018). Genetic cartography of longevity in humans and mice: Current landscape and horizons. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1864 (9 Pt A), 2718-2732. doi:10.1016/j.bbadis.2018.01.026
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Liu, Y., Borel, C., Li, L., Muller, T., WILLIAMS, E., Germain, P.-L., Buljan, M., Sajic, T., Boersema, P. J., Shao, W., Faini, M., Testa, G., Beyer, A., Antonarakis, S. E., & Aebersold, R. (2017). Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells. Nature Communications, 8 (1), 1212. doi:10.1038/s41467-017-01422-6
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Wu, Y., WILLIAMS, E., & Aebersold, R. (2017). Application of SWATH Proteomics to Mouse Biology. Current Protocols in Mouse Biology, 7 (2), 130-143. doi:10.1002/cpmo.28
Peer reviewed

Williams, R. W., & WILLIAMS, E. (2017). Resources for Systems Genetics. Methods in Molecular Biology, 1488, 3-29. doi:10.1007/978-1-4939-6427-7_1
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Wang, X., Pandey, A. K., Mulligan, M. K., WILLIAMS, E., Mozhui, K., Li, Z., Jovaisaite, V., Quarles, L. D., Xiao, Z., Huang, J., Capra, J. A., Chen, Z., Taylor, W. L., Bastarache, L., Niu, X., Pollard, K. S., Ciobanu, D. C., Reznik, A. O., Tishkov, A. V., ... Williams, R. W. (2016). Joint mouse-human phenome-wide association to test gene function and disease risk. Nature Communications, 7, 10464. doi:10.1038/ncomms10464
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Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-Dit-Felix, A. A., WILLIAMS, E., Jha, P., Lo Sasso, G., Huzard, D., Aebischer, P., Sandi, C., Rinsch, C., & Auwerx, J. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature Medicine, 22 (8), 879-88. doi:10.1038/nm.4132
Peer Reviewed verified by ORBi

Merkwirth, C., Jovaisaite, V., Durieux, J., Matilainen, O., Jordan, S. D., Quiros, P. M., Steffen, K. K., WILLIAMS, E., Mouchiroud, L., Tronnes, S. U., Murillo, V., Wolff, S. C., Shaw, R. J., Auwerx, J., & Dillin, A. (2016). Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity. Cell, 165 (5), 1209-1223. doi:10.1016/j.cell.2016.04.012
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Mouchiroud, L., Sorrentino, V., WILLIAMS, E., Cornaglia, M., Frochaux, M. V., Lin, T., Nicolet-Dit-Felix, A. A., Krishnamani, G., Ouhmad, T., Gijs, M. A. M., Deplancke, B., & Auwerx, J. (2016). The Movement Tracker: A Flexible System for Automated Movement Analysis in Invertebrate Model Organisms. Current Protocols in Neuroscience, 77, 8.37.1-8.37.21. doi:10.1002/cpns.17
Peer reviewed

WILLIAMS, E., Wu, Y., Jha, P., Dubuis, S., Blattmann, P., Argmann, C. A., Houten, S. M., Amariuta, T., Wolski, W., Zamboni, N., Aebersold, R., & Auwerx, J. (2016). Systems proteomics of liver mitochondria function. Science, 352 (6291), 0189. doi:10.1126/science.aad0189
Peer Reviewed verified by ORBi

van de Weijer, T., Phielix, E., Bilet, L., WILLIAMS, E., Ropelle, E. R., Bierwagen, A., Livingstone, R., Nowotny, P., Sparks, L. M., Paglialunga, S., Szendroedi, J., Havekes, B., Moullan, N., Pirinen, E., Hwang, J.-H., Schrauwen-Hinderling, V. B., Hesselink, M. K. C., Auwerx, J., Roden, M., & Schrauwen, P. (2015). Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans. Diabetes, 64 (4), 1193-201. doi:10.2337/db14-0667
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WILLIAMS, E., & Auwerx, J. (2015). The Convergence of Systems and Reductionist Approaches in Complex Trait Analysis. Cell, 162 (1), 23-32. doi:10.1016/j.cell.2015.06.024
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Moullan, N., Mouchiroud, L., Wang, X., Ryu, D., WILLIAMS, E., Mottis, A., Jovaisaite, V., Frochaux, M. V., Quiros, P. M., Deplancke, B., Houtkooper, R. H., & Auwerx, J. (2015). Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research. Cell Reports, 10 (10), 1681-1691. doi:10.1016/j.celrep.2015.02.034
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Hasenfuss, S. C., Bakiri, L., Thomsen, M. K., WILLIAMS, E., Auwerx, J., & Wagner, E. F. (2014). Regulation of steatohepatitis and PPARgamma signaling by distinct AP-1 dimers. Cell Metabolism, 19 (1), 84-95. doi:10.1016/j.cmet.2013.11.018
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Pirinen, E., Canto, C., Jo, Y. S., Morato, L., Zhang, H., Menzies, K. J., WILLIAMS, E., Mouchiroud, L., Moullan, N., Hagberg, C., Li, W., Timmers, S., Imhof, R., Verbeek, J., Pujol, A., van Loon, B., Viscomi, C., Zeviani, M., Schrauwen, P., ... Auwerx, J. (2014). Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle. Cell Metabolism, 19 (6), 1034-41. doi:10.1016/j.cmet.2014.04.002
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Wu, Y., WILLIAMS, E., Dubuis, S., Mottis, A., Jovaisaite, V., Houten, S. M., Argmann, C. A., Faridi, P., Wolski, W., Kutalik, Z., Zamboni, N., Auwerx, J., & Aebersold, R. (2014). Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population. Cell, 158 (6), 1415-1430. doi:10.1016/j.cell.2014.07.039
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WILLIAMS, E., Mouchiroud, L., Frochaux, M., Pandey, A., Andreux, P. A., Deplancke, B., & Auwerx, J. (2014). An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement. PLoS Genetics, 10 (9), 1004673. doi:10.1371/journal.pgen.1004673
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Andreux, P. A., WILLIAMS, E., Koutnikova, H., Houtkooper, R. H., Champy, M.-F., Henry, H., Schoonjans, K., Williams, R. W., & Auwerx, J. (2012). Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits. Cell, 150 (6), 1287-99. doi:10.1016/j.cell.2012.08.012
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McKnite, A. M., Perez-Munoz, M. E., Lu, L., WILLIAMS, E., Brewer, S., Andreux, P. A., Bastiaansen, J. W. M., Wang, X., Kachman, S. D., Auwerx, J., Williams, R. W., Benson, A. K., Peterson, D. A., & Ciobanu, D. C. (2012). Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits. PLoS ONE, 7 (6), 39191. doi:10.1371/journal.pone.0039191
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Yamamoto, H., WILLIAMS, E., Mouchiroud, L., Canto, C., Fan, W., Downes, M., Heligon, C., Barish, G. D., Desvergne, B., Evans, R. M., Schoonjans, K., & Auwerx, J. (2011). NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell, 147 (4), 827-39. doi:10.1016/j.cell.2011.10.017
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