  | Allayee, H., Farber, C. R., Seldin, M. M., WILLIAMS, E., James, D. E., & Lusis, A. J. (14 November 2023). Systems genetics approaches for understanding complex traits with relevance for human disease. eLife, 12. doi:10.7554/eLife.91004  Peer Reviewed verified by ORBi |
 | Li, X., Morel, J.-D., Benegiamo, G., Poisson, J., Bachmann, A., Rapin, A., Sulc, J., WILLIAMS, E., Perino, A., Schoonjans, K., Bou Sleiman, M., & Auwerx, J. (19 October 2023). Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population. eLife, 12. doi:10.7554/eLife.87569 Peer Reviewed verified by ORBi |
 | Xu, F., Ziebarth, J. D., Goeminne, L. J., Gao, J., WILLIAMS, E., Quarles, L. D., Makowski, L., Cui, Y., Williams, R. W., Auwerx, J., & Lu, L. (September 2023). Gene network based analysis identifies a coexpression module involved in regulating plasma lipids with high-fat diet response. Journal of Nutritional Biochemistry, 119, 109398. doi:10.1016/j.jnutbio.2023.109398 Peer Reviewed verified by ORBi |
 | Li, H., Perino, A., Huang, Q., von Alvensleben, G., Banaei-Esfahani, A., Velazquez-Villegas, L., Gariani, K., Korbelius, M., Bou Sleiman, M., Imbach, J., Sun, Y., Li, X., Bachmann, A., Goeminne, L., Gallart-Ayala, H., Williams, E., Ivanisevic, J., Auwerx, J., & Schoonjans, K. (04 October 2022). Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis. Cell Metabolism, 34 (10), 1594-1610. doi:10.1016/j.cmet.2022.08.015 Peer Reviewed verified by ORBi |
 | Sharma, V., Fossati, A., Ciuffa, R., Buljan, M., Williams, E., Chen, Z., Shao, W., Pedrioli, P., Purcell, A., Rodriguez Martinez, M., Song, J., Manica, M., Aebersold, R., & Li, C. (23 July 2022). PCfun: a hybrid computational framework for systematic characterization of protein complex function. Briefings in Bioinformatics, 23 (4), 239. doi:10.1093/bib/bbac239 Peer Reviewed verified by ORBi |
 | Addicks, G., Zhang, H., Ryu, D., Vasam, G., Green, A., Marshall, P., Patel, S., Kang, B., Kim, D., Katsyuba, E., Williams, E., Renaud, J.-M., Auwerx, J., & Menzies, K. (07 February 2022). GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression. Journal of Cell Biology, 221 (2). doi:10.1083/jcb.202104022 Peer Reviewed verified by ORBi |
 | Morel, J.-D., Sauzéat, L., Goeminne, L., Jha, P., Williams, E., Houtkooper, R., Auwerx, J., & Balter, V. (01 February 2022). The mouse metallomic landscape of aging and metabolism. Nature Communications, 13 (607). doi:10.1038/s41467-022-28060-x Peer Reviewed verified by ORBi |
 | Williams, E., Pfister, N., Roy, S., Statzer, C., Haverty, J., Ingels, J., Bohl, C., Hasan, M., Cuklina, J., Bühlmann, P., Zamboni, N., Lu, L., Ewald, C., Williams, R., & Aebersold, R. (19 January 2022). Multiomic profiling of the liver across diets and age in a diverse mouse population. Cell Systems, 13 (1), 43-57. doi:10.1016/j.cels.2021.09.005 Peer Reviewed verified by ORBi |
 | van der Kolk, B. W., Saari, S., Lovric, A., Arif, M., Alvarez, M., Ko, A., Miao, Z., Sahebekhtiari, N., Muniandy, M., Heinonen, S., Oghabian, A., Jokinen, R., Jukarainen, S., Hakkarainen, A., Lundbom, J., Kuula, J., Groop, P.-H., Tukiainen, T., Lundbom, N., ... Pietiläinen, K. H. (2021). Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI. Cell Reports Medicine, 2 (4), 100226. doi:10.1016/j.xcrm.2021.100226 Peer Reviewed verified by ORBi |
 | Ashbrook, D. G., Arends, D., Prins, P., Mulligan, M. K., Roy, S., Williams, E., Lutz, C. M., Valenzuela, A., Bohl, C. J., Ingels, J. F., McCarty, M. S., Centeno, A. G., Hager, R., Auwerx, J., Lu, L., & Williams, R. W. (2021). A platform for experimental precision medicine: The extended BXD mouse family. Cell Systems, 12 (3), 235-247.e9. doi:10.1016/j.cels.2020.12.002 Peer Reviewed verified by ORBi |
 | Čuklina, J., Lee, C. H., Williams, E., Sajic, T., Collins, B. C., Rodríguez Martínez, M., Sharma, V. S., Wendt, F., Goetze, S., Keele, G. R., Wollscheid, B., Aebersold, R., & Pedrioli, P. G. A. (2021). Diagnostics and correction of batch effects in large-scale proteomic studies: a tutorial. Molecular Systems Biology, 17 (8), 10240. doi:10.15252/msb.202110240 Peer Reviewed verified by ORBi |
  | Roy, S., Bou Sleiman, M., Jha, P., Ingels, J., Chapman, C., McCarty, M., Ziebarth, J., Hook, M., Sun, A., Zhao, W., Huang, J., Neuner, S., Wilmott, L., Shapaker, T., Centeno, A., Ashbrook, D., Mulligan, M., Kaczorowski, C., Makowski, L., ... Williams, R. (2021). Gene-by-environment modulation of lifespan and weight gain in the murine BXD family. Nature Metabolism. doi:10.1038/s42255-021-00449-w Peer reviewed |
 | Pfister, N., Williams, E., Peters, J., Aebersold, R., & Bühlmann, P. (2021). Stabilizing variable selection and regression. Annals of Applied Statistics, 15 (3). doi:10.1214/21-AOAS1487 Peer Reviewed verified by ORBi |
 | Molenaars, M., Janssens, G. E., Williams, E., Jongejan, A., Lan, J., Rabot, S., Joly, F., Moerland, P. D., Schomakers, B. V., Lezzerini, M., Liu, Y. J., McCormick, M. A., Kennedy, B. K., van Weeghel, M., van Kampen, A. H. C., Aebersold, R., MacInnes, A. W., & Houtkooper, R. H. (2020). A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways. Cell Metabolism, 31 (3), 549-563.e7. doi:10.1016/j.cmet.2020.01.011 Peer Reviewed verified by ORBi |
 | Liu, Y. J., McIntyre, R. L., Janssens, G. E., Williams, E., Lan, J., van Weeghel, M., Schomakers, B., van der Veen, H., van der Wel, N. N., Yao, P., Mair, W. B., Aebersold, R., MacInnes, A. W., & Houtkooper, R. H. (2020). Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30. The Journal of cell biology, 219 (6). doi:10.1083/jcb.201907067 Peer reviewed |
 | Rosenberger, G., Heusel, M., Bludau, I., Collins, B. C., Martelli, C., Williams, E., Xue, P., Liu, Y., Aebersold, R., & Califano, A. (2020). SECAT: Quantifying Protein Complex Dynamics across Cell States by Network-Centric Analysis of SEC-SWATH-MS Profiles. Cell Systems, 11 (6), 589-607.e8. doi:10.1016/j.cels.2020.11.006 Peer Reviewed verified by ORBi |
 | Sandoval-Sierra, J. V., Helbing, A. H. B., Williams, E., Ashbrook, D. G., Roy, S., Williams, R. W., & Mozhui, K. (2020). Body weight and high-fat diet are associated with epigenetic aging in female members of the BXD murine family. Aging cell, 19 (9), 13207. doi:10.1111/acel.13207 Peer reviewed |
 | Liu, Y., Mi, Y., Mueller, T., Kreibich, S., Williams, E., Van Drogen, A., Borel, C., Frank, M., Germain, P.-L., Bludau, I., Mehnert, M., Seifert, M., Emmenlauer, M., Sorg, I., Bezrukov, F., Bena, F. S., Zhou, H., Dehio, C., Testa, G., ... Aebersold, R. (2019). Multi-omic measurements of heterogeneity in HeLa cells across laboratories. Nature Biotechnology, 37 (3), 314-322. doi:10.1038/s41587-019-0037-y Peer Reviewed verified by ORBi |
 | Sajic, T., Ciuffa, R., Lemos, V., Xu, P., Leone, V., Li, C., Williams, E., Makris, G., Banaei-Esfahani, A., Heikenwalder, M., Schoonjans, K., & Aebersold, R. (2019). A new class of protein biomarkers based on subcellular distribution: application to a mouse liver cancer model. Scientific Reports, 9 (1), 6913. doi:10.1038/s41598-019-43091-z Peer Reviewed verified by ORBi |
 | Perez-Munoz, M. E., McKnite, A. M., Williams, E., Auwerx, J., Williams, R. W., Peterson, D. A., & Ciobanu, D. C. (2019). Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population. PLoS ONE, 14 (10), 0224100. doi:10.1371/journal.pone.0224100 Peer Reviewed verified by ORBi |
 | Williams, E., & Stein, S. (2019). JCAD: from systems genetics identification to the experimental validation of a coronary artery disease risk locus. European Heart Journal, 40 (29), 2409-2412. doi:10.1093/eurheartj/ehz370 Peer Reviewed verified by ORBi |
 | Leandro, J., Violante, S., Argmann, C. A., Hagen, J., Dodatko, T., Bender, A., Zhang, W., Williams, E., Bachmann, A. M., Auwerx, J., Yu, C., & Houten, S. M. (2019). Mild inborn errors of metabolism in commonly used inbred mouse strains. Molecular Genetics and Metabolism, 126 (4), 388-396. doi:10.1016/j.ymgme.2019.01.021 Peer Reviewed verified by ORBi |
 | Williams, E., Wu, Y., Wolski, W., Kim, J. Y., Lan, J., Hasan, M., Halter, C., Jha, P., Ryu, D., Auwerx, J., & Aebersold, R. (2018). Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population. Molecular and Cellular Proteomics, 17 (9), 1766-1777. doi:10.1074/mcp.RA118.000554 Peer Reviewed verified by ORBi |
 | Hook, M., Roy, S., Williams, E., Bou Sleiman, M., Mozhui, K., Nelson, J. F., Lu, L., Auwerx, J., & Williams, R. W. (2018). Genetic cartography of longevity in humans and mice: Current landscape and horizons. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1864 (9 Pt A), 2718-2732. doi:10.1016/j.bbadis.2018.01.026 Peer Reviewed verified by ORBi |
 | Jha, P., McDevitt, M. T., Halilbasic, E., Williams, E., Quiros, P. M., Gariani, K., Sleiman, M. B., Gupta, R., Ulbrich, A., Jochem, A., Coon, J. J., Trauner, M., Pagliarini, D. J., & Auwerx, J. (2018). Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes. Cell systems, 6 (6), 709-721.e6. doi:10.1016/j.cels.2018.05.009 Peer reviewed |
 | Sajic, T., Liu, Y., Arvaniti, E., Surinova, S., Williams, E., Schiess, R., Huttenhain, R., Sethi, A., Pan, S., Brentnall, T. A., Chen, R., Blattmann, P., Friedrich, B., Nimeus, E., Malander, S., Omlin, A., Gillessen, S., Claassen, M., & Aebersold, R. (2018). Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS. Cell Reports, 23 (9), 2819-2831.e5. doi:10.1016/j.celrep.2018.04.114 Peer Reviewed verified by ORBi |
 | Jha, P., McDevitt, M. T., Gupta, R., Quiros, P. M., Williams, E., Gariani, K., Sleiman, M. B., Diserens, L., Jochem, A., Ulbrich, A., Coon, J. J., Auwerx, J., & Pagliarini, D. J. (2018). Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species. Cell systems, 6 (6), 722-733.e6. doi:10.1016/j.cels.2018.05.016 Peer reviewed |
 | Wu, Y., Williams, E., & Aebersold, R. (2017). Application of SWATH Proteomics to Mouse Biology. Current Protocols in Mouse Biology, 7 (2), 130-143. doi:10.1002/cpmo.28 Peer reviewed |
 | Liu, Y., Borel, C., Li, L., Muller, T., Williams, E., Germain, P.-L., Buljan, M., Sajic, T., Boersema, P. J., Shao, W., Faini, M., Testa, G., Beyer, A., Antonarakis, S. E., & Aebersold, R. (2017). Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells. Nature Communications, 8 (1), 1212. doi:10.1038/s41467-017-01422-6 Peer Reviewed verified by ORBi |
 | Williams, R. W., & Williams, E. (2017). Resources for Systems Genetics. Methods in Molecular Biology, 1488, 3-29. doi:10.1007/978-1-4939-6427-7_1 Peer Reviewed verified by ORBi |
 | Wang, X., Pandey, A. K., Mulligan, M. K., Williams, E., Mozhui, K., Li, Z., Jovaisaite, V., Quarles, L. D., Xiao, Z., Huang, J., Capra, J. A., Chen, Z., Taylor, W. L., Bastarache, L., Niu, X., Pollard, K. S., Ciobanu, D. C., Reznik, A. O., Tishkov, A. V., ... Williams, R. W. (2016). Joint mouse-human phenome-wide association to test gene function and disease risk. Nature Communications, 7, 10464. doi:10.1038/ncomms10464 Peer Reviewed verified by ORBi |
 | Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-Dit-Felix, A. A., Williams, E., Jha, P., Lo Sasso, G., Huzard, D., Aebischer, P., Sandi, C., Rinsch, C., & Auwerx, J. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature Medicine, 22 (8), 879-88. doi:10.1038/nm.4132 Peer Reviewed verified by ORBi |
 | Merkwirth, C., Jovaisaite, V., Durieux, J., Matilainen, O., Jordan, S. D., Quiros, P. M., Steffen, K. K., Williams, E., Mouchiroud, L., Tronnes, S. U., Murillo, V., Wolff, S. C., Shaw, R. J., Auwerx, J., & Dillin, A. (2016). Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity. Cell, 165 (5), 1209-1223. doi:10.1016/j.cell.2016.04.012 Peer Reviewed verified by ORBi |
 | Mouchiroud, L., Sorrentino, V., Williams, E., Cornaglia, M., Frochaux, M. V., Lin, T., Nicolet-Dit-Felix, A. A., Krishnamani, G., Ouhmad, T., Gijs, M. A. M., Deplancke, B., & Auwerx, J. (2016). The Movement Tracker: A Flexible System for Automated Movement Analysis in Invertebrate Model Organisms. Current Protocols in Neuroscience, 77, 8.37.1-8.37.21. doi:10.1002/cpns.17 Peer reviewed |
 | Williams, E., Wu, Y., Jha, P., Dubuis, S., Blattmann, P., Argmann, C. A., Houten, S. M., Amariuta, T., Wolski, W., Zamboni, N., Aebersold, R., & Auwerx, J. (2016). Systems proteomics of liver mitochondria function. Science, 352 (6291), 0189. doi:10.1126/science.aad0189 Peer Reviewed verified by ORBi |
 | van de Weijer, T., Phielix, E., Bilet, L., Williams, E., Ropelle, E. R., Bierwagen, A., Livingstone, R., Nowotny, P., Sparks, L. M., Paglialunga, S., Szendroedi, J., Havekes, B., Moullan, N., Pirinen, E., Hwang, J.-H., Schrauwen-Hinderling, V. B., Hesselink, M. K. C., Auwerx, J., Roden, M., & Schrauwen, P. (2015). Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans. Diabetes, 64 (4), 1193-201. doi:10.2337/db14-0667 Peer Reviewed verified by ORBi |
 | Williams, E., & Auwerx, J. (2015). The Convergence of Systems and Reductionist Approaches in Complex Trait Analysis. Cell, 162 (1), 23-32. doi:10.1016/j.cell.2015.06.024 Peer Reviewed verified by ORBi |
 | Moullan, N., Mouchiroud, L., Wang, X., Ryu, D., Williams, E., Mottis, A., Jovaisaite, V., Frochaux, M. V., Quiros, P. M., Deplancke, B., Houtkooper, R. H., & Auwerx, J. (2015). Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research. Cell Reports, 10 (10), 1681-1691. doi:10.1016/j.celrep.2015.02.034 Peer Reviewed verified by ORBi |
 | Pirinen, E., Canto, C., Jo, Y. S., Morato, L., Zhang, H., Menzies, K. J., Williams, E., Mouchiroud, L., Moullan, N., Hagberg, C., Li, W., Timmers, S., Imhof, R., Verbeek, J., Pujol, A., van Loon, B., Viscomi, C., Zeviani, M., Schrauwen, P., ... Auwerx, J. (2014). Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle. Cell Metabolism, 19 (6), 1034-41. doi:10.1016/j.cmet.2014.04.002 Peer Reviewed verified by ORBi |
 | Hasenfuss, S. C., Bakiri, L., Thomsen, M. K., Williams, E., Auwerx, J., & Wagner, E. F. (2014). Regulation of steatohepatitis and PPARgamma signaling by distinct AP-1 dimers. Cell Metabolism, 19 (1), 84-95. doi:10.1016/j.cmet.2013.11.018 Peer Reviewed verified by ORBi |
 | Williams, E., Mouchiroud, L., Frochaux, M., Pandey, A., Andreux, P. A., Deplancke, B., & Auwerx, J. (2014). An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement. PLoS Genetics, 10 (9), 1004673. doi:10.1371/journal.pgen.1004673 Peer Reviewed verified by ORBi |
 | Wu, Y., Williams, E., Dubuis, S., Mottis, A., Jovaisaite, V., Houten, S. M., Argmann, C. A., Faridi, P., Wolski, W., Kutalik, Z., Zamboni, N., Auwerx, J., & Aebersold, R. (2014). Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population. Cell, 158 (6), 1415-1430. doi:10.1016/j.cell.2014.07.039 Peer Reviewed verified by ORBi |
 | McKnite, A. M., Perez-Munoz, M. E., Lu, L., Williams, E., Brewer, S., Andreux, P. A., Bastiaansen, J. W. M., Wang, X., Kachman, S. D., Auwerx, J., Williams, R. W., Benson, A. K., Peterson, D. A., & Ciobanu, D. C. (2012). Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits. PLoS ONE, 7 (6), 39191. doi:10.1371/journal.pone.0039191 Peer Reviewed verified by ORBi |
 | Andreux, P. A., Williams, E., Koutnikova, H., Houtkooper, R. H., Champy, M.-F., Henry, H., Schoonjans, K., Williams, R. W., & Auwerx, J. (2012). Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits. Cell, 150 (6), 1287-99. doi:10.1016/j.cell.2012.08.012 Peer Reviewed verified by ORBi |
 | Yamamoto, H., Williams, E., Mouchiroud, L., Canto, C., Fan, W., Downes, M., Heligon, C., Barish, G. D., Desvergne, B., Evans, R. M., Schoonjans, K., & Auwerx, J. (2011). NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell, 147 (4), 827-39. doi:10.1016/j.cell.2011.10.017 Peer Reviewed verified by ORBi |
