Reference : Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multio...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/48045
Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI.
English
van der Kolk, Birgitta W. [> >]
Saari, Sina [> >]
Lovric, Alen [> >]
Arif, Muhammad [> >]
Alvarez, Marcus [> >]
Ko, Arthur [> >]
Miao, Zong [> >]
Sahebekhtiari, Navid [> >]
Muniandy, Maheswary [> >]
Heinonen, Sini [> >]
Oghabian, Ali [> >]
Jokinen, Riikka [> >]
Jukarainen, Sakari [> >]
Hakkarainen, Antti [> >]
Lundbom, Jesper [> >]
Kuula, Juho [> >]
Groop, Per-Henrik [> >]
Tukiainen, Taru [> >]
Lundbom, Nina [> >]
Rissanen, Aila [> >]
Kaprio, Jaakko [> >]
Williams, Evan mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Gene Expression and Metabolism]
Zamboni, Nicola [> >]
Mardinoglu, Adil [> >]
Pajukanta, Päivi [> >]
Pietiläinen, Kirsi H. [> >]
2021
Cell reports. Medicine
2
4
100226
Yes
2666-3791
2666-3791
[en] adipose tissue ; genome-scale metabolic models ; metabolomics ; multiomics ; obesity ; proteomics ; skeletal muscle ; transcriptomics ; twins
[en] Tissue-specific mechanisms prompting obesity-related development complications in humans remain unclear. We apply multiomics analyses of subcutaneous adipose tissue and skeletal muscle to examine the effects of acquired obesity among 49 BMI-discordant monozygotic twin pairs. Overall, adipose tissue appears to be more affected by excess body weight than skeletal muscle. In heavier co-twins, we observe a transcriptional pattern of downregulated mitochondrial pathways in both tissues and upregulated inflammatory pathways in adipose tissue. In adipose tissue, heavier co-twins exhibit lower creatine levels; in skeletal muscle, glycolysis- and redox stress-related protein and metabolite levels remain higher. Furthermore, metabolomics analyses in both tissues reveal that several proinflammatory lipids are higher and six of the same lipid derivatives are lower in acquired obesity. Finally, in adipose tissue, but not in skeletal muscle, mitochondrial downregulation and upregulated inflammation are associated with a fatty liver, insulin resistance, and dyslipidemia, suggesting that adipose tissue dominates in acquired obesity.
http://hdl.handle.net/10993/48045
© 2021 The Authors.

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
00_FINAL_MS.pdfPublisher postprint2.42 MBView/Open

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.