Reference : Loss of Ambra1 promotes melanoma growth and invasion.
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
Systems Biomedicine
http://hdl.handle.net/10993/47062
Loss of Ambra1 promotes melanoma growth and invasion.
English
Di Leo, Luca [> >]
Bodemeyer, Valérie [> >]
Bosisio, Francesca M. [> >]
Claps, Giuseppina [> >]
Carretta, Marco [> >]
Rizza, Salvatore [> >]
Faienza, Fiorella [> >]
Frias, Alex [> >]
Khan, Shawez [> >]
Bordi, Matteo [> >]
Pires Pacheco, Maria Irene mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
Di Martino, Julie [> >]
Bravo-Cordero, Jose J. [> >]
Daniel, Colin J. [> >]
Sears, Rosalie C. [> >]
Donia, Marco [> >]
Madsen, Daniel H. [> >]
Guldberg, Per [> >]
Filomeni, Giuseppe [> >]
Sauter, Thomas mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM)]
Robert, Caroline [> >]
De Zio, Daniela [> >]
Cecconi, Francesco [> >]
2021
Nature communications
12
1
2550
Yes
2041-1723
2041-1723
England
[en] Melanoma is the deadliest skin cancer. Despite improvements in the understanding of the molecular mechanisms underlying melanoma biology and in defining new curative strategies, the therapeutic needs for this disease have not yet been fulfilled. Herein, we provide evidence that the Activating Molecule in Beclin-1-Regulated Autophagy (Ambra1) contributes to melanoma development. Indeed, we show that Ambra1 deficiency confers accelerated tumor growth and decreased overall survival in Braf/Pten-mutated mouse models of melanoma. Also, we demonstrate that Ambra1 deletion promotes melanoma aggressiveness and metastasis by increasing cell motility/invasion and activating an EMT-like process. Moreover, we show that Ambra1 deficiency in melanoma impacts extracellular matrix remodeling and induces hyperactivation of the focal adhesion kinase 1 (FAK1) signaling, whose inhibition is able to reduce cell invasion and melanoma growth. Overall, our findings identify a function for AMBRA1 as tumor suppressor in melanoma, proposing FAK1 inhibition as a therapeutic strategy for AMBRA1 low-expressing melanoma.
Researchers
http://hdl.handle.net/10993/47062

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
s41467-021-22772-2.pdfPublisher postprint4.85 MBView/Open

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.