Abstract :
[en] The dynamic organization of the actin cytoskeleton into bundles and networks is
orchestrated by a large variety of actin-binding proteins. Among them, the actinbundling
protein L-plastin is normally expressed in hematopoietic cells, where it is
involved in the immune response. However, L-plastin is also often ectopically expressed
in malignant cancer cells of non-hematopoietic origin and is even considered as a
marker for cancer progression. Post-translational modification modulates L-plastin activity.
In particular, L-plastin Ser5 phosphorylation has been shown to be important for the
immune response in leukocytes as well as for invasion and metastasis formation of
carcinoma cells.
Name of the research project :
Analysis of the signal transduction network upstream of L-plastin Ser5 phosphorylation in breast cancer cells and tissues
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