Reference : The actin-bundling protein L-plastin—A double-edged sword: Beneficial for the immune ... |
Parts of books : Contribution to collective works | |||
Life sciences : Biochemistry, biophysics & molecular biology | |||
Systems Biomedicine | |||
http://hdl.handle.net/10993/46706 | |||
The actin-bundling protein L-plastin—A double-edged sword: Beneficial for the immune response, maleficent in cancer | |
English | |
Schaffner-Reckinger, Elisabeth ![]() | |
Machado, Raquel A.C. ![]() | |
2020 | |
Actin Cytoskeleton in Cancer Progression and Metastasis - Part A | |
INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY | |
Elsevier | |
Volume 355 | |
109-154 | |
Yes | |
978-0-12-821281-3 | |
Amsterdam | |
The Netherlands | |
[en] L-plastin ; actin ; actin-binding protein ; phosphorylation ; immune response ; invasion ; metastasis ; cancer | |
[en] The dynamic organization of the actin cytoskeleton into bundles and networks is
orchestrated by a large variety of actin-binding proteins. Among them, the actinbundling protein L-plastin is normally expressed in hematopoietic cells, where it is involved in the immune response. However, L-plastin is also often ectopically expressed in malignant cancer cells of non-hematopoietic origin and is even considered as a marker for cancer progression. Post-translational modification modulates L-plastin activity. In particular, L-plastin Ser5 phosphorylation has been shown to be important for the immune response in leukocytes as well as for invasion and metastasis formation of carcinoma cells. | |
Fondation Cancer (FC/2016/04) | |
Analysis of the signal transduction network upstream of L-plastin Ser5 phosphorylation in breast cancer cells and tissues | |
Researchers ; Professionals | |
http://hdl.handle.net/10993/46706 | |
10.1016/bs.ircmb.2020.05.004 |
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