Reference : The actin-bundling protein L-plastin—A double-edged sword: Beneficial for the immune ...

	Document type :	Parts of books : Contribution to collective works
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	Focus Areas :	Systems Biomedicine
	To cite this reference:	http://hdl.handle.net/10993/46706

Title :	The actin-bundling protein L-plastin—A double-edged sword: Beneficial for the immune response, maleficent in cancer
Language :	English
Author, co-author :	Schaffner-Reckinger, Elisabeth [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
	Machado, Raquel A.C. [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) > PostDoc]
Publication date :	2020
Edition :	Actin Cytoskeleton in Cancer Progression and Metastasis - Part A
Main document title :	INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY
Publisher :	Elsevier
Collection and collection volume :	Volume 355
Pages :	109-154
Peer reviewed :	Yes
ISBN :	978-0-12-821281-3
City :	Amsterdam
Country :	The Netherlands
Keywords :	[en] L-plastin ; actin ; actin-binding protein ; phosphorylation ; immune response ; invasion ; metastasis ; cancer
Abstract :	[en] The dynamic organization of the actin cytoskeleton into bundles and networks is orchestrated by a large variety of actin-binding proteins. Among them, the actinbundling protein L-plastin is normally expressed in hematopoietic cells, where it is involved in the immune response. However, L-plastin is also often ectopically expressed in malignant cancer cells of non-hematopoietic origin and is even considered as a marker for cancer progression. Post-translational modification modulates L-plastin activity. In particular, L-plastin Ser5 phosphorylation has been shown to be important for the immune response in leukocytes as well as for invasion and metastasis formation of carcinoma cells.
Funders :	Fondation Cancer (FC/2016/04)
Name of the research project :	Analysis of the signal transduction network upstream of L-plastin Ser5 phosphorylation in breast cancer cells and tissues
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/10993/46706
DOI :	10.1016/bs.ircmb.2020.05.004

	File(s) associated to this reference
	Fulltext file(s): File Commentary Version Size Access Limited access E. Schaffner-Reckinger and R.A.C. Machado, IRCMB, 2020.pdf Publisher postprint 500.98 kB Request a copy

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