Reference : The actin-bundling protein L-plastin—A double-edged sword: Beneficial for the immune ...
Parts of books : Contribution to collective works
Life sciences : Biochemistry, biophysics & molecular biology
Systems Biomedicine
http://hdl.handle.net/10993/46706
The actin-bundling protein L-plastin—A double-edged sword: Beneficial for the immune response, maleficent in cancer
English
Schaffner-Reckinger, Elisabeth mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
Machado, Raquel A.C. mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) > PostDoc]
2020
Actin Cytoskeleton in Cancer Progression and Metastasis - Part A
INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY
Elsevier
Volume 355
109-154
Yes
978-0-12-821281-3
Amsterdam
The Netherlands
[en] L-plastin ; actin ; actin-binding protein ; phosphorylation ; immune response ; invasion ; metastasis ; cancer
[en] The dynamic organization of the actin cytoskeleton into bundles and networks is
orchestrated by a large variety of actin-binding proteins. Among them, the actinbundling
protein L-plastin is normally expressed in hematopoietic cells, where it is
involved in the immune response. However, L-plastin is also often ectopically expressed
in malignant cancer cells of non-hematopoietic origin and is even considered as a
marker for cancer progression. Post-translational modification modulates L-plastin activity.
In particular, L-plastin Ser5 phosphorylation has been shown to be important for the
immune response in leukocytes as well as for invasion and metastasis formation of
carcinoma cells.
Fondation Cancer (FC/2016/04)
Analysis of the signal transduction network upstream of L-plastin Ser5 phosphorylation in breast cancer cells and tissues
Researchers ; Professionals
http://hdl.handle.net/10993/46706
10.1016/bs.ircmb.2020.05.004

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