Reference : Replication of a Novel Parkinson's Locus in a European Ancestry Population
Scientific journals : Article
Life sciences : Genetics & genetic processes
Systems Biomedicine
http://hdl.handle.net/10993/46664
Replication of a Novel Parkinson's Locus in a European Ancestry Population
English
Grover, Sandeep [> >]
Kumar-Sreelatha, Ashwin Ashok [> >]
Bobbili, Dheeraj R. [> >]
May, Patrick mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Bioinformatics Core]
Domenighetti, Cloé [> >]
Sugier, Pierre-Emmanuel [> >]
Schulte, Claudia [> >]
COURAGE-PD Consortium [> >]
Elbaz, Alexis [> >]
Krüger, Rejko mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience]
Gasser, Thomas [> >]
Sharma, Manu [> >]
24-Mar-2021
Movement Disorders
Yes
International
0885-3185
[en] ABSTRACT Background A recently published East Asian genome-wide association study of Parkinson;s disease (PD) reported 2 novel risk loci, SV2C and WBSCR17. Objectives The objective of this study were to determine whether recently reported novel SV2C and WBSCR17 loci contribute to the risk of developing PD in European and East Asian ancestry populations. Methods We report an association analysis of recently reported variants with PD in the COURAGE-PD cohort (9673 PD patients; 8465 controls) comprising individuals of European and East Asian ancestries. In addition, publicly available summary data (41,386 PD patients; 476,428 controls) were pooled. Results Our findings confirmed the role of the SV2C variant in PD pathogenesis (rs246814, COURAGE-PD PEuropean = 6.64 × 10−4, pooled PD P = 1.15 × 10−11). The WBSCR17 rs9638616 was observed as a significant risk marker in the East Asian pooled population only (P = 1.16 × 10−8). Conclusions Our comprehensive study provides an up-to-date summary of recently detected novel loci in different PD populations and confirmed the role of SV2C locus as a novel risk factor for PD irrespective of the population or ethnic group analyzed. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
Luxembourg Centre for Systems Biomedicine (LCSB): Bioinformatics Core (R. Schneider Group) ; Luxembourg Centre for Systems Biomedicine (LCSB): Clinical & Experimental Neuroscience (Krüger Group)
PEARL programme (FNR/P13/6682797)
JPND Courage-PD
Researchers ; Professionals
http://hdl.handle.net/10993/46664
10.1002/mds.28546
https://movementdisorders.onlinelibrary.wiley.com/doi/abs/10.1002/mds.28546
FnR ; FNR11264123 > Rejko Krüger > > Ncer-pd > 01/01/2015 > 30/11/2020 > 2015

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