Article (Scientific journals)
Mapping the Metabolic Networks of Tumor Cells and Cancer-Associated Fibroblasts
Karta, Jessica; Bossicard, Ysaline; Kotzamanis, Konstantinos et al.
2021In Cells
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Keywords :
cancer-associated fibroblasts; CAF-tumor cross-talk; tumor metabolism
Abstract :
[en] Metabolism is considered to be the core of all cellular activity. Thus, extensive studies of metabolic processes are ongoing in various fields of biology, including cancer research. Cancer cells are known to adapt their metabolism to sustain high proliferation rates and survive in unfavorable environments with low oxygen and nutrient concentrations. Hence, targeting cancer cell metabolism is a promising therapeutic strategy in cancer research. However, cancers consist not only of genetically altered tumor cells but are interwoven with endothelial cells, immune cells and fibroblasts, which together with the extracellular matrix (ECM) constitute the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs), which are linked to poor prognosis in different cancer types, are one important component of the TME. CAFs play a significant role in reprogramming the metabolic landscape of tumor cells, but how, and in what manner, this interaction takes place remains rather unclear. This review aims to highlight the metabolic landscape of tumor cells and CAFs, including their recently identified subtypes, in different tumor types. In addition, we discuss various in vitro and in vivo metabolic techniques as well as different in silico computational tools that can be used to identify and characterize CAF–tumor cell interactions. Finally, we provide our view on how mapping the complex metabolic networks of stromal-tumor metabolism will help in finding novel metabolic targets for cancer treatment.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Karta, Jessica ;  University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM)
Bossicard, Ysaline ;  University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM)
Kotzamanis, Konstantinos ;  University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM)
Dolznig, Helmut;  Institute of Medical Genetics, Medical University of Vienna, Vienna, Austria
Letellier, Elisabeth ;  University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM)
External co-authors :
yes
Language :
English
Title :
Mapping the Metabolic Networks of Tumor Cells and Cancer-Associated Fibroblasts
Publication date :
02 February 2021
Journal title :
Cells
ISSN :
2073-4409
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Basel, Switzerland
Peer reviewed :
Peer Reviewed verified by ORBi
FnR Project :
FNR12554295 - Prognostic Gene Classifier In Stage Ii Colorectal Cancer, 2018 (15/09/2018-14/09/2021) - Elisabeth Letellier
Funders :
FNR - Fonds National de la Recherche [LU]
Fondation Marie-Jeanne and Edmond Schumacher
Fondation Gustave and Simone Prévot
Fondation du Pélican de Mie and Pierre Hippert-Faber
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