Reference : Mapping the Metabolic Networks of Tumor Cells and Cancer-Associated Fibroblasts
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/10993/46600
Mapping the Metabolic Networks of Tumor Cells and Cancer-Associated Fibroblasts
English
Karta, Jessica mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
Bossicard, Ysaline mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
Kotzamanis, Konstantinos mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
Dolznig, Helmut [Institute of Medical Genetics, Medical University of Vienna, Vienna, Austria]
Letellier, Elisabeth mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
2-Feb-2021
Cells
Multidisciplinary Digital Publishing Institute (MDPI)
Yes (verified by ORBilu)
International
2073-4409
Basel
Switzerland
[en] cancer-associated fibroblasts ; CAF-tumor cross-talk ; tumor metabolism
[en] Metabolism is considered to be the core of all cellular activity. Thus, extensive studies of metabolic processes are ongoing in various fields of biology, including cancer research. Cancer cells are known to adapt their metabolism to sustain high proliferation rates and survive in unfavorable environments with low oxygen and nutrient concentrations. Hence, targeting cancer cell metabolism is a promising therapeutic strategy in cancer research. However, cancers consist not only of genetically altered tumor cells but are interwoven with endothelial cells, immune cells and fibroblasts, which together with the extracellular matrix (ECM) constitute the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs), which are linked to poor prognosis in different cancer types, are one important component of the TME. CAFs play a significant role in reprogramming the metabolic landscape of tumor cells, but how, and in what manner, this interaction takes place remains rather unclear. This review aims to highlight the metabolic landscape of tumor cells and CAFs, including their recently identified subtypes, in different tumor types. In addition, we discuss various in vitro and in vivo metabolic techniques as well as different in silico computational tools that can be used to identify and characterize CAF–tumor cell interactions. Finally, we provide our view on how mapping the complex metabolic networks of stromal-tumor metabolism will help in finding novel metabolic targets for cancer treatment.
Fonds National de la Recherche - FnR ; Fondation Marie-Jeanne and Edmond Schumacher ; Fondation Gustave and Simone Prévot ; Fondation du Pélican de Mie and Pierre Hippert-Faber
Researchers
http://hdl.handle.net/10993/46600
10.3390/cells10020304
FnR ; FNR12554295 > Elisabeth Letellier > MyoRPROG > Prognostic Gene Classifier In Stage Ii Colorectal Cancer > 15/09/2018 > 14/09/2021 > 2018

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Karta et al., 2021.pdfPublisher postprint964 kBView/Open

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.