Article (Scientific journals)
Increased Circulating VAP-1 Levels Are Associated with Liver Fibrosis in Chronic Hepatitis C Infection.
Kraemer, Marcel; Krawczyk, Marcin; NOOR, Fozia et al.
2019In Journal of Clinical Medicine, 8 (1)
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Keywords :
Fibroscan; HCV; SSAO activity; VAP-1; chronic liver diseases; fibrosis; liver stiffness; semicarbazide-sensitive amino oxidase; vascular adhesion protein 1
Abstract :
[en] Vascular adhesion protein-1 (VAP-1) is a multifunction protein. While membrane-bound VAP-1 is an adhesion protein, soluble VAP-1 catalyzes the deamination of primary amines through its semicarbazide-sensitive amino oxidase (SSAO) activity. VAP-1 supports the transmigration of leukocytes and increases oxidative stress. In chronic liver diseases, it plays a role in leukocyte infiltration and fibrogenesis. Here, we measured VAP-1 plasma concentration and its SSAO activity in 322 patients with chronic hepatitis C infection and evaluated the association of VAP-1 with fibrosis stages. VAP-1 concentration strongly correlated with liver stiffness and was the second strongest influencing variable after gamma-glutamytransferase (GGT) for liver stiffness in regression analysis. The VAP-1 concentration increased with advancing fibrosis stages and the highest concentrations were found in patients with cirrhosis. According to the receiver operating characteristic (ROC) analysis, a VAP-1 cut-off value of 541 ng/mL predicted histologically confirmed cirrhosis (sensitivity 74%; specificity 72%). SSAO activity correlated only moderately with liver stiffness, showing a relatively small increase in advanced fibrosis. To our knowledge, this is the first study on VAP-1 in chronic hepatitis C infection showing its association with progressive fibrosis. In conclusion, VAP-1 plasma concentration, rather than its SSAO activity, may represent a non-invasive biomarker for monitoring fibrogenesis in patients with chronic hepatitis C infection.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Kraemer, Marcel
Krawczyk, Marcin
NOOR, Fozia ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Grunhage, Frank
Lammert, Frank
SCHNEIDER, Jochen ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
External co-authors :
Language :
Title :
Increased Circulating VAP-1 Levels Are Associated with Liver Fibrosis in Chronic Hepatitis C Infection.
Publication date :
Journal title :
Journal of Clinical Medicine
Publisher :
MDPI, Basel, Switzerland
Volume :
Issue :
Peer reviewed :
Peer Reviewed verified by ORBi
Focus Area :
Systems Biomedicine
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