Article (Scientific journals)
Recent development and biomedical applications of probabilistic Boolean networks
TRAIRATPHISAN, Panuwat; MIZERA, Andrzej; PANG, Jun et al.
2013In Cell Communication and Signaling, 11 (46)
Peer Reviewed verified by ORBi
 

Files


Full Text
[Formatted_Full_Text]1478-811X-11-46.pdf
Publisher postprint (1.03 MB)
Provisional manuscript (published 1st July 2013), full text will be available and updated later
Download

All documents in ORBilu are protected by a user license.

Send to



Details



Keywords :
probabilistic Boolean networks; Probabilistic graphical models; Qualitative modelling; Systems biology
Abstract :
[en] Probabilistic Boolean network (PBN) modelling is a semi-quantitative approach widely used for the study of the topology and dynamic aspects of biological systems. The combined use of rule-based representation and probability makes PBN appealing for large-scale modelling of biological networks where degrees of uncertainty need to be considered. A considerable expansion of our knowledge in the field of theoretical research on PBN can be observed over the past few years, with a focus on network inference, network intervention and control. With respect to areas of applications, PBN is mainly used for the study of gene regulatory networks though with an increasing emergence in signal transduction, metabolic, and also physiological networks. At the same time, a number of computational tools, facilitating the modelling and analysis of PBNs, are continuously developed. A concise yet comprehensive review of the state-of-the-art on PBN modelling is offered in this article, including a comparative discussion on PBN versus similar models with respect to concepts and biomedical applications. Due to their many advantages, we consider PBN to stand as a suitable modelling framework for the description and analysis of complex biological systems, ranging from molecular to physiological levels.
Research center :
Life Sciences Research Unit
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
TRAIRATPHISAN, Panuwat ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
MIZERA, Andrzej ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Computer Science and Communications Research Unit (CSC)
PANG, Jun  ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Computer Science and Communications Research Unit (CSC) ; University of Luxembourg > Interdisciplinary Centre for Security, Reliability and Trust (SNT)
TANTAR, Alexandru-Adrian ;  University of Luxembourg > Interdisciplinary Centre for Security, Reliability and Trust (SNT)
SCHNEIDER, Jochen ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
SAUTER, Thomas ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Language :
English
Title :
Recent development and biomedical applications of probabilistic Boolean networks
Publication date :
01 July 2013
Journal title :
Cell Communication and Signaling
ISSN :
1478-811X
Publisher :
BioMed Central
Special issue title :
Systems Biology and Medicine
Volume :
11
Issue :
46
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FNR - Fonds National de la Recherche [LU]
Available on ORBilu :
since 03 August 2013

Statistics


Number of views
243 (32 by Unilu)
Number of downloads
151 (15 by Unilu)

Scopus citations®
 
79
Scopus citations®
without self-citations
59
WoS citations
 
75

Bibliography


Similar publications



Contact ORBilu