[en] The view that myosins, which are actin based molecular motors, are only driving muscle
contraction evolved a lot during the last decades. Nowadays, it is known that they
reshape the actin skeleton, anchor or transport vesicles, organelles as well as protein
complexes. Here, we review how their role in cell division, polarization, migration
and death is related to the cancer phenotype. We will further focus our attention
on recent evidences suggesting that these central roles make them prime biomarker
candidates for the prognosis of various cancers. Finally, we will discuss emerging evidences
raising myosins as new therapeutic targets to fight malignant tumors.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Letellier, Elisabeth ; University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM)
Koncina, Eric ; University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM)
External co-authors :
no
Language :
English
Title :
Myosins: Driving us towards novel targets and biomarkers in cancer
Publication date :
2020
Main work title :
Actin Cytoskeleton in Cancer Progression and Metastasis - Part B
Publisher :
Elsevier
ISBN/EAN :
978-0-12-821283-7
Pages :
291-322
Peer reviewed :
Peer reviewed
Focus Area :
Systems Biomedicine
FnR Project :
FNR11282028 - Role Of Mir-371-373 Cluster In Tumor Initiation And Metastatic Colonization, 2016 (15/03/2017-14/07/2020) - Elisabeth Letellier
Funders :
The Foundation Cancer (F1R-LSCPAU- 13HY2C), the Proof of Concept grant (PoC18/12554295) through the FNR, the Foundation Vera Nijs and Jens Erik Rosborg.
