Reference : Myosins: Driving us towards novel targets and biomarkers in cancer
Parts of books : Contribution to collective works
Life sciences : Biochemistry, biophysics & molecular biology
Systems Biomedicine
http://hdl.handle.net/10993/45563
Myosins: Driving us towards novel targets and biomarkers in cancer
English
Letellier, Elisabeth mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
Koncina, Eric mailto [University of Luxembourg > Faculty of Science, Technology and Medicine (FSTM) > Department of Life Sciences and Medicine (DLSM) >]
2020
Actin Cytoskeleton in Cancer Progression and Metastasis - Part B
Elsevier
291-322
Yes
978-0-12-821283-7
[en] myosin ; cancer ; biomarkers
[en] The view that myosins, which are actin based molecular motors, are only driving muscle
contraction evolved a lot during the last decades. Nowadays, it is known that they
reshape the actin skeleton, anchor or transport vesicles, organelles as well as protein
complexes. Here, we review how their role in cell division, polarization, migration
and death is related to the cancer phenotype. We will further focus our attention
on recent evidences suggesting that these central roles make them prime biomarker
candidates for the prognosis of various cancers. Finally, we will discuss emerging evidences
raising myosins as new therapeutic targets to fight malignant tumors.
The Foundation Cancer (F1R-LSCPAU- 13HY2C), the Proof of Concept grant (PoC18/12554295) through the FNR, the Foundation Vera Nijs and Jens Erik Rosborg.
Researchers ; Professionals
http://hdl.handle.net/10993/45563
10.1016/bs.ircmb.2020.06.004
FnR ; FNR11282028 > Elisabeth Letellier > miRMet > Role of miR-371-373 cluster in tumor initiation and metastatic colonization > 15/03/2017 > 14/03/2020 > 2016

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