Article (Scientific journals)
Die Geschichte des ‚Freezing-of-gait‘ beim Parkinson-Syndrom – vom Phänomen zum Symptom.
Klucken, Jochen; Winkler, Juergen; Krüger, Rejko et al.
2020In Fortschritte der Neurologie-Psychiatrie, 88 (9), p. 573-581
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Keywords :
Gait; Gait Disorders, Neurologic/complications/physiopathology; Humans; Parkinson Disease/complications/physiopathology
Abstract :
[en] The background of the freezing-of-gait (FOG) phenomenon in Parkinson's syndrome is presented in this review. The following issues are addressed: characterization of the symptom freezing and its subtypes that challenge standardized diagnostic procedures; available assessment methods generating freezing-related parameters that not only support clinical studies but can also be applied in everyday care, and current therapy options. FOG exists in different subtypes, and clinical and diagnostic definitions are limited by subjective characterization and semi-standardized tests. FOG-specific drug options are not existing, apart from the optimization of dopaminergic medication, which may also be due to the poor discriminatory power of standardized diagnostics. This is also true for deep brain stimulation. Both of these therapeutic options may be due not only to the complex neural network alterations as a motor-control correlate of FOG, but also because of challenging diagnostic assessments methodologies. Innovative, wearable, sensor-based diagnostic strategies are currently being developed, and supportive therapies using tools and technologies focusing on 'cueing' are becoming increasingly well accepted. Even though high level evidence is missing, they provide a helpful treatment option for individualized therapy. It can be assumed that these options will become particularly popular due to technological progress and likely alter the everyday treatment challenges faced by doctors and therapists.
Disciplines :
Author, co-author :
Klucken, Jochen
Winkler, Juergen
Krüger, Rejko ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
Jost, Wolfgang
External co-authors :
Language :
Title :
Die Geschichte des ‚Freezing-of-gait‘ beim Parkinson-Syndrom – vom Phänomen zum Symptom.
Alternative titles :
[en] The history of Freezing-of-gait in Parkinson's disease - from phenomena to symptom
Publication date :
Journal title :
Fortschritte der Neurologie-Psychiatrie
Publisher :
Georg Thieme Verlag, Germany
Volume :
Issue :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
Focus Area :
Systems Biomedicine
Commentary :
© Georg Thieme Verlag KG Stuttgart · New York.
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since 12 January 2021


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