Reference : Contributing Factors and Evolution of Impulse Control Disorder in the Luxembourg Park...
Scientific journals : Article
Human health sciences : Neurology
Systems Biomedicine
http://hdl.handle.net/10993/45304
Contributing Factors and Evolution of Impulse Control Disorder in the Luxembourg Parkinson Cohort.
English
Binck, Sylvia [Centre Hospitalier de Luxembourg]
Pauly, Claire mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience]
Vaillant, Michel [Luxembourg Institute of Health - LIH]
Hipp, Geraldine [> >]
Gantenbein, Manon [Luxembourg Institute of Health - LIH]
Krüger, Rejko mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience]
Diederich, Nico J. [Centre Hospitalier de Luxembourg]
2020
Frontiers in neurology
11
578924
Yes (verified by ORBilu)
International
1664-2295
1664-2295
[en] Parkinson's disease (PD) ; dopamine agonists ; impulse control disorder ; longitudinal analysis ; risk factors
[en] Background: To establish the frequency of impulse control disorder (ICD) in Parkinson's disease (PD). Methods: Within the Luxembourg Parkinson's Study, PD patients were evaluated for ICD presence (score ≥ 1 on MDS-UPDRS I item 1.6), use of dopamine agonists (DA) and other medications. Results: 470 patients were enrolled. Among 217 patients without DA use, 6.9% scored positive for ICD, vs. 15.4% among 253 patients with DA use (p = 0.005). The regression analysis showed that age at PD diagnosis had only a minor impact on ICD occurrence, while there was no influence by gender or co-medications. The longitudinal study over 2 years in 156 patients demonstrated increasing ICD frequency in DA users (p = 0.005). Conclusion: This large and non-interventional study confirms that PD patients with DA treatment show higher frequency of ICD than patients without DA use. It newly demonstrates that ICD can develop independently from age, gender, or co-medications.
Researchers ; Professionals ; Students
http://hdl.handle.net/10993/45304
10.3389/fneur.2020.578924
https://www.frontiersin.org/articles/10.3389/fneur.2020.578924/full
OA
Copyright © 2020 Binck, Pauly, Vaillant, Hipp, Gantenbein, Krueger and Diederich.
FnR ; FNR12719664 > Rejko Krüger > MOTASYN-PD > Modelling therapy development in Parkinson’s disease based on patient-derived iPSC lines harbouring pathogenic mutations in the SNCA gene > 01/10/2018 > 30/09/2021 > 2018

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