Article (Scientific journals)
Contributing Factors and Evolution of Impulse Control Disorder in the Luxembourg Parkinson Cohort.
Binck, Sylvia; Pauly, Claire; Vaillant, Michel et al.
2020In Frontiers in Neurology, 11, p. 578924
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Keywords :
Parkinson's disease (PD); dopamine agonists; impulse control disorder; longitudinal analysis; risk factors
Abstract :
[en] Background: To establish the frequency of impulse control disorder (ICD) in Parkinson's disease (PD). Methods: Within the Luxembourg Parkinson's Study, PD patients were evaluated for ICD presence (score ≥ 1 on MDS-UPDRS I item 1.6), use of dopamine agonists (DA) and other medications. Results: 470 patients were enrolled. Among 217 patients without DA use, 6.9% scored positive for ICD, vs. 15.4% among 253 patients with DA use (p = 0.005). The regression analysis showed that age at PD diagnosis had only a minor impact on ICD occurrence, while there was no influence by gender or co-medications. The longitudinal study over 2 years in 156 patients demonstrated increasing ICD frequency in DA users (p = 0.005). Conclusion: This large and non-interventional study confirms that PD patients with DA treatment show higher frequency of ICD than patients without DA use. It newly demonstrates that ICD can develop independently from age, gender, or co-medications.
Disciplines :
Neurology
Author, co-author :
Binck, Sylvia ;  Centre Hospitalier de Luxembourg
Pauly, Claire ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
Vaillant, Michel;  Luxembourg Institute of Health - LIH
Hipp, Geraldine
Gantenbein, Manon;  Luxembourg Institute of Health - LIH
Krüger, Rejko ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > Translational Neuroscience
Diederich, Nico J.;  Centre Hospitalier de Luxembourg
External co-authors :
no
Language :
English
Title :
Contributing Factors and Evolution of Impulse Control Disorder in the Luxembourg Parkinson Cohort.
Publication date :
2020
Journal title :
Frontiers in Neurology
ISSN :
1664-2295
Publisher :
Frontiers Media S.A., Switzerland
Volume :
11
Pages :
578924
Peer reviewed :
Peer Reviewed verified by ORBi
Focus Area :
Systems Biomedicine
FnR Project :
FNR12719664 - Modelling Therapy Development In Parkinson'S Disease Based On Patient-derived Ipsc Lines Harbouring Pathogenic Mutations In The Snca Gene, 2018 (01/10/2018-31/05/2022) - Rejko Krüger
Commentary :
Copyright © 2020 Binck, Pauly, Vaillant, Hipp, Gantenbein, Krueger and Diederich.
Available on ORBilu :
since 04 January 2021

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