Reference : Digital twinning of Cellular Capsule Technology: emerging outcomes from the perspecti...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Multidisciplinary, general & others
Systems Biomedicine
http://hdl.handle.net/10993/44133
Digital twinning of Cellular Capsule Technology: emerging outcomes from the perspective of porous media mechanics
English
Urcun, Stéphane mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > >]
12-Jul-2021
PLoS ONE
Public Library of Science
Yes (verified by ORBilu)
International
1932-6203
San Franscisco
CA
[en] Multicellular spheroid ; Computational biomechanics ; Multiphase poromechanics
[en] Spheroids encapsulated within alginate capsules are emerging as suitable in vitro tools to investigate the impact of mechanical forces on tumor growth since the internal tumor pressure can be retrieved from the deformation of the capsule. Here we focus on the particular case of Cellular Capsule Technology (CCT). We show in this contribution that a modeling approach accounting for the triphasic nature of the spheroid (extracellular matrix, tumor cells and interstitial fluid) offers a new perspective of analysis revealing that the pressure retrieved experimentally cannot be interpreted as a direct picture of the pressure sustained by the tumor cells and, as such, cannot therefore be used to quantify the critical pressure which induces stress-induced phenotype switch in tumor cells. The proposed multiphase reactive poro-mechanical model was cross-validated. Parameter sensitivity analyses on the digital twin revealed that the main parameters determining the encapsulated growth configuration are different from those driving growth in free condition, confirming that radically different phenomena are at play. Results reported in this contribution support the idea that multiphase reactive poro-mechanics is an exceptional theoretical framework to attain an in-depth understanding of CCT experiments, to confirm their hypotheses and to further improve their design.

We show in this contribution that a modeling approach accounting for the triphasic nature of the spheroid (extracellular matrix, tumor cells and interstitial fluid) offers a new perspective of analysis revealing that the pressure retrieved experimentally cannot be interpreted as a direct picture of the pressure sustained by the tumor cells and, as such, cannot therefore be used to quantify the critical pressure which induces stress-induced phenotype switch in tumour cells.

The proposed multiphase reactive poro-mechanical model was cross-validated. Parameter sensitivity analyses on the digital twin revealed that the main parameters determining the encapsulated growth configuration are different from those driving growth in free condition, confirming that radically different phenomena are at play.Results reported in this contribution support the idea that multiphase reactive poro-mechanics is an exceptional theoretical framework to attain an in-depth understanding of CCT experiments, to confirm their hypotheses and to further improve their design.
ENSAM réseau santé, Université du Luxembourg, DRIVEN H2020 TWINNING
Researchers
http://hdl.handle.net/10993/44133
10.1371/journal.pone.0254512
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254512

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