Reference : NCoR1 is a conserved physiological modulator of muscle mass and oxidative function.
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/10993/43165
NCoR1 is a conserved physiological modulator of muscle mass and oxidative function.
English
Yamamoto, Hiroyasu [> >]
Williams, Evan mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Mouchiroud, Laurent [> >]
Canto, Carles [> >]
Fan, Weiwei [> >]
Downes, Michael [> >]
Heligon, Christophe [> >]
Barish, Grant D. [> >]
Desvergne, Beatrice [> >]
Evans, Ronald M. [> >]
Schoonjans, Kristina [> >]
Auwerx, Johan [> >]
2011
Cell
147
4
827-39
Yes (verified by ORBilu)
0092-8674
1097-4172
United States
[en] Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/genetics/metabolism ; Gene Deletion ; Gene Knockdown Techniques ; Humans ; Mice ; Mitochondria, Muscle/metabolism ; Muscle Development ; Muscle, Skeletal/metabolism ; Nuclear Receptor Co-Repressor 1/genetics/metabolism ; PPAR delta/metabolism ; PPAR-beta/metabolism ; Physical Conditioning, Animal
[en] Transcriptional coregulators control the activity of many transcription factors and are thought to have wide-ranging effects on gene expression patterns. We show here that muscle-specific loss of nuclear receptor corepressor 1 (NCoR1) in mice leads to enhanced exercise endurance due to an increase of both muscle mass and of mitochondrial number and activity. The activation of selected transcription factors that control muscle function, such as MEF2, PPARbeta/delta, and ERRs, underpins these phenotypic alterations. NCoR1 levels are decreased in conditions that require fat oxidation, resetting transcriptional programs to boost oxidative metabolism. Knockdown of gei-8, the sole C. elegans NCoR homolog, also robustly increased muscle mitochondria and respiration, suggesting conservation of NCoR1 function. Collectively, our data suggest that NCoR1 plays an adaptive role in muscle physiology and that interference with NCoR1 action could be used to improve muscle function.
Researchers
http://hdl.handle.net/10993/43165
Copyright (c) 2011 Elsevier Inc. All rights reserved.

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