Article (Scientific journals)
Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits.
Andreux, Penelope A.; Williams, Evan; Koutnikova, Hana et al.
2012In Cell, 150 (6), p. 1287-99
Peer Reviewed verified by ORBi
 

Files


Full Text
00. Final AndreuxWilliamsCell2012.pdf
Publisher postprint (1 MB)
Download

All documents in ORBilu are protected by a user license.

Send to



Details



Keywords :
Alkaline Phosphatase/chemistry/genetics; Animals; Crosses, Genetic; Disease Models, Animal; Female; Homeostasis; Humans; Hypophosphatasia/genetics; Male; Metabolic Diseases/genetics; Mice/genetics; Mice, Inbred C57BL; Mice, Inbred DBA; Polymorphism, Genetic; Quantitative Trait Loci; Reference Standards; Vitamin B 6/metabolism
Abstract :
[en] Metabolic homeostasis is achieved by complex molecular and cellular networks that differ significantly among individuals and are difficult to model with genetically engineered lines of mice optimized to study single gene function. Here, we systematically acquired metabolic phenotypes by using the EUMODIC EMPReSS protocols across a large panel of isogenic but diverse strains of mice (BXD type) to study the genetic control of metabolism. We generated and analyzed 140 classical phenotypes and deposited these in an open-access web service for systems genetics (www.genenetwork.org). Heritability, influence of sex, and genetic modifiers of traits were examined singly and jointly by using quantitative-trait locus (QTL) and expression QTL-mapping methods. Traits and networks were linked to loci encompassing both known variants and novel candidate genes, including alkaline phosphatase (ALPL), here linked to hypophosphatasia. The assembled and curated phenotypes provide key resources and exemplars that can be used to dissect complex metabolic traits and disorders.
Disciplines :
Genetics & genetic processes
Author, co-author :
Andreux, Penelope A.
Williams, Evan  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Koutnikova, Hana
Houtkooper, Riekelt H.
Champy, Marie-France
Henry, Hugues
Schoonjans, Kristina
Williams, Robert W.
Auwerx, Johan
External co-authors :
yes
Language :
English
Title :
Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits.
Publication date :
2012
Journal title :
Cell
ISSN :
1097-4172
Publisher :
Cell Press, United States - Massachusetts
Volume :
150
Issue :
6
Pages :
1287-99
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2012 Elsevier Inc. All rights reserved.
Available on ORBilu :
since 11 May 2020

Statistics


Number of views
49 (0 by Unilu)
Number of downloads
35 (0 by Unilu)

Scopus citations®
 
170
Scopus citations®
without self-citations
134
OpenCitations
 
174
WoS citations
 
164

Bibliography


Similar publications



Contact ORBilu