Article (Scientific journals)
Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS.
Sajic, Tatjana; Liu, Yansheng; Arvaniti, Eirini et al.
2018In Cell Reports, 23 (9), p. 2819-2831.e5
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Keywords :
Algorithms; Blood Platelets/metabolism; Carcinoma/blood/genetics/pathology; Cohort Studies; Glycoproteins/blood; Humans; Mass Spectrometry/methods; Neoplasm Staging; Oncogenes; Proteome/metabolism; ROC Curve; SWATH-mass spectrometry; blood; carcinoma; glycoproteins; human clinical study; localized cancer; secreted
Abstract :
[en] Cancer is mostly incurable when diagnosed at a metastatic stage, making its early detection via blood proteins of immense clinical interest. Proteomic changes in tumor tissue may lead to changes detectable in the protein composition of circulating blood plasma. Using a proteomic workflow combining N-glycosite enrichment and SWATH mass spectrometry, we generate a data resource of 284 blood samples derived from patients with different types of localized-stage carcinomas and from matched controls. We observe whether the changes in the patient's plasma are specific to a particular carcinoma or represent a generic signature of proteins modified uniformly in a common, systemic response to many cancers. A quantitative comparison of the resulting N-glycosite profiles discovers that proteins related to blood platelets are common to several cancers (e.g., THBS1), whereas others are highly cancer-type specific. Available proteomics data, including a SWATH library to study N-glycoproteins, will facilitate follow-up biomarker research into early cancer detection.
Disciplines :
Genetics & genetic processes
Author, co-author :
Sajic, Tatjana
Liu, Yansheng
Arvaniti, Eirini
Surinova, Silvia
WILLIAMS, Evan  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Schiess, Ralph
Huttenhain, Ruth
Sethi, Atul
Pan, Sheng
Brentnall, Teresa A.
Chen, Ru
Blattmann, Peter
Friedrich, Betty
Nimeus, Emma
Malander, Susanne
Omlin, Aurelius
Gillessen, Silke
Claassen, Manfred
Aebersold, Ruedi
More authors (9 more) Less
External co-authors :
yes
Language :
English
Title :
Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS.
Publication date :
2018
Journal title :
Cell Reports
eISSN :
2211-1247
Publisher :
Elsevier, Amsterdam, Netherlands
Volume :
23
Issue :
9
Pages :
2819-2831.e5
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2018 The Author(s). Published by Elsevier Inc. All rights reserved.
Available on ORBilu :
since 11 May 2020

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