Reference : The Convergence of Systems and Reductionist Approaches in Complex Trait Analysis.
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/10993/43070
The Convergence of Systems and Reductionist Approaches in Complex Trait Analysis.
English
Williams, Evan mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Auwerx, Johan [> >]
2015
Cell
162
1
23-32
Yes (verified by ORBilu)
0092-8674
1097-4172
United States
[en] Animals ; Gene Regulatory Networks ; Gene-Environment Interaction ; Genome-Wide Association Study ; Humans ; Phenotype ; Plants/genetics
[en] Research into the genetic and environmental factors behind complex trait variation has traditionally been segregated into distinct scientific camps. The reductionist approach aims to decrypt phenotypic variability bit by bit, founded on the underlying hypothesis that genome-to-phenome relations are largely constructed from the additive effects of their molecular players. In contrast, the systems approach aims to examine large-scale interactions of many components simultaneously, on the premise that interactions in gene networks can be both linear and non-linear. Both approaches are complementary, and they are becoming increasingly intertwined due to developments in gene editing tools, omics technologies, and population resources. Together, these strategies are beginning to drive the next era in complex trait research, paving the way to improve agriculture and toward more personalized medicine.
http://hdl.handle.net/10993/43070
Copyright (c) 2015 Elsevier Inc. All rights reserved.

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