Reference : Gene-environment interaction and Mendelian randomisation
Scientific journals : Article
Human health sciences : Neurology
Systems Biomedicine
Gene-environment interaction and Mendelian randomisation
Krüger, Rejko mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Kolber, Pierre Luc mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
Revue Neurologique
Elsevier Masson
Yes (verified by ORBilu)
[en] Parkinson's disease ; Mendelian randomisation ; Gene-environment interaction
[en] Genetic factors only account for up to a third of the cases of Parkinson's disease (PD), while the remaining cases are of unknown aetiology. Environmental exposures (such as pesticides or heavy metals) and the interaction with genetic susceptibility factors (summarized in the concept of impaired xenobiotic metabolism) are believed to play a major role in the mechanisms of neurodegeneration. Beside of the classical association studies (e.g. genome-wide association studies), a novel approach to investigate environmental risk factors are Mendelian randomisation studies. This review explores the gene-environment interaction and the gain of Mendelian randomisation studies in assessing causalities of modifiable risk factors for PD.
Researchers ; Professionals
Open Access
FnR ; FNR6682797 > Rejko Krüger > Endophenotypes in Neurodegeneration > Comprehensive assessment of endophenotypes in neurodegenerative diseases - translating impaired molecular signalling pathways into novel therapeutic strategies for Parkinson’s disease > 01/06/2014 > 31/05/2019 > 2013

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