Reference : Gene-environment interaction and Mendelian randomisation
Scientific journals : Article
Human health sciences : Neurology
Systems Biomedicine
http://hdl.handle.net/10993/42313
Gene-environment interaction and Mendelian randomisation
English
Krüger, Rejko mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Kolber, Pierre Luc mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) > >]
1-Dec-2019
Revue Neurologique
Elsevier Masson
Yes (verified by ORBilu)
International
0035-3787
2213-0004
Paris
France
[en] Parkinson's disease ; Mendelian randomisation ; Gene-environment interaction
[en] Genetic factors only account for up to a third of the cases of Parkinson's disease (PD), while the remaining cases are of unknown aetiology. Environmental exposures (such as pesticides or heavy metals) and the interaction with genetic susceptibility factors (summarized in the concept of impaired xenobiotic metabolism) are believed to play a major role in the mechanisms of neurodegeneration. Beside of the classical association studies (e.g. genome-wide association studies), a novel approach to investigate environmental risk factors are Mendelian randomisation studies. This review explores the gene-environment interaction and the gain of Mendelian randomisation studies in assessing causalities of modifiable risk factors for PD.
Researchers ; Professionals
http://hdl.handle.net/10993/42313
10.1016/j.neurol.2019.04.010
https://www.sciencedirect.com/science/article/pii/S0035378719306009?via%3Dihub
Open Access
FnR ; FNR6682797 > Rejko Krüger > Endophenotypes in Neurodegeneration > Comprehensive assessment of endophenotypes in neurodegenerative diseases - translating impaired molecular signalling pathways into novel therapeutic strategies for Parkinson’s disease > 01/06/2014 > 31/05/2019 > 2013

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Gene-environment interaction and Mendelian randomisation.pdfPublisher postprint824.86 kBView/Open

Bookmark and Share SFX Query

All documents in ORBilu are protected by a user license.