Article (Scientific journals)
The exposome and health: Where chemistry meets biology
Vermeulen, Roel; Schymanski, Emma; Barabási, Albert-László et al.
2020In Science, 367 (6476), p. 392--396
Peer reviewed
 

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Abstract :
[en] Despite extensive evidence showing that exposure to specific chemicals can lead to disease, current research approaches and regulatory policies fail to address the chemical complexity of our world. To safeguard current and future generations from the increasing number of chemicals polluting our environment, a systematic and agnostic approach is needed. The \textquotedblleftexposome\textquotedblright concept strives to capture the diversity and range of exposures to synthetic chemicals, dietary constituents, psychosocial stressors, and physical factors, as well as their corresponding biological responses. Technological advances such as high-resolution mass spectrometry and network science have allowed us to take the first steps toward a comprehensive assessment of the exposome. Given the increased recognition of the dominant role that nongenetic factors play in disease, an effort to characterize the exposome at a scale comparable to that of the human genome is warranted.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Vermeulen, Roel
Schymanski, Emma  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Barabási, Albert-László
Miller, Gary W.
External co-authors :
yes
Language :
English
Title :
The exposome and health: Where chemistry meets biology
Publication date :
2020
Journal title :
Science
ISSN :
0036-8075
Publisher :
American Association for the Advancement of Science
Volume :
367
Issue :
6476
Pages :
392--396
Peer reviewed :
Peer reviewed
FnR Project :
FNR12341006 - Environmental Cheminformatics To Identify Unknown Chemicals And Their Effects, 2018 (01/10/2018-30/09/2023) - Emma Schymanski
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