Reference : The Gut Microbiota and Hematopoietic Stem Cell Transplantation: Challenges and Potentials.
Scientific journals : Article
Human health sciences : Gastroenterology & hepatology
http://hdl.handle.net/10993/38895
The Gut Microbiota and Hematopoietic Stem Cell Transplantation: Challenges and Potentials.
English
Noor, Fozia mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Kaysen, Anne mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Wilmes, Paul mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
Schneider, Jochen mailto [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >]
2018
Journal of innate immunity
1-11
Yes (verified by ORBilu)
International
1662-811X
1662-8128
Switzerland
[en] Graft-versus-host disease ; Gut microbiota ; Immune system ; Microbiome ; Stem cell transplantation
[en] The human gut microbiota gained tremendous importance in the last decade as next-generation technologies of sequencing and multiomics analyses linked the role of the microbial communities to host physiology and pathophysiology. A growing number of human pathologies and diseases are linked to the gut microbiota. One of the main mechanisms by which the microbiota influences the host is through its interactions with the host immune system. These interactions with both innate and adaptive host intestinal and extraintestinal immunity, although usually commensalistic even mutualistic with the host, in some cases lead to serious health effects. In the case of allogenic hematopoietic stem cell transplantation (allo-HSCT), the disruption of the intestinal microbiota diversity is associated with acute graft-versus-host disease (GvHD). Causing inflammation of the liver, skin, lungs, and the intestine, GvHD occurs in 40-50% of patients undergoing allo-HSCT and results in significant posttransplantation mortality. In this review, we highlight the impact of the gut microbiota on the host immunity in GvHD and the potential of microbiota in alleviation or even prevention of GvHD.
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/10993/38895
(c) 2018 The Author(s) Published by S. Karger AG, Basel.

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