Article (Scientific journals)
Itaconic acid indicates cellular but not systemic immune system activation
Meiser, Johannes; Kraemer, Lisa; Jäger, Christian et al.
2018In Oncotarget, 9 (63)
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Keywords :
itaconic acid; metabolism; sepsis; biomarker; inflammation; immunology
Abstract :
[en] Itaconic acid is produced by mammalian leukocytes upon pro-inflammatory activation. It appears to inhibit bacterial growth and to rewire the metabolism of the host cell by inhibiting succinate dehydrogenase. Yet, it is unknown whether itaconic acid acts only intracellularly, locally in a paracrine fashion, or whether it is even secreted from the inflammatory cells at meaningful levels in peripheral blood of patients with severe inflammation or sepsis. The aim of this study was to determine the release rate of itaconic acid from pro-inflammatory activated macrophages in vitro and to test for the abundance of itaconic acid in bodyfluids of patients suffering from acute inflammation. We demonstrate that excretion of itaconic acid happens at a low rate and that it cannot be detected in significant amounts in plasma or urine of septic patients or in liquid from bronchial lavage of patients with pulmonary inflammation. We conclude that itaconic acid may serve as a pro-inflammatory marker in immune cells but that it does not qualify as a biomarker in the tested body fluids.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Meiser, Johannes
Kraemer, Lisa
Jäger, Christian  ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
Madry, Henning
Link, Andreas
Lepper, Philipp M.
Hiller, Karsten
Schneider, Jochen ;  University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB)
External co-authors :
yes
Language :
English
Title :
Itaconic acid indicates cellular but not systemic immune system activation
Publication date :
2018
Journal title :
Oncotarget
eISSN :
1949-2553
Publisher :
Impact Journals, United States - New York
Volume :
9
Issue :
63
Peer reviewed :
Peer Reviewed verified by ORBi
Focus Area :
Systems Biomedicine
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