Article (Scientific journals)
Regulatory feedback loop between TP73 and TRIM32.
Gonzalez-Cano, L.; Hillje, Anna-Lena; Fuertes-Alvarez, S. et al.
2013In Cell Death and Disease, 4, p. 704
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Abstract :
[en] The p73 transcription factor is one of the members of the p53 family of tumor suppressors with unique biological functions in processes like neurogenesis, embryonic development and differentiation. For this reason, p73 activity is tightly regulated by multiple mechanisms, including transcription and post-translational modifications. Here, we identified a novel regulatory loop between TAp73 and the E3 ubiquitin ligase tripartite motif protein 32 (TRIM32). TRIM32, a new direct p73 transcriptional target in the context of neural progenitor cells, is differentially regulated by p73. Although TAp73 binds to the TRIM32 promoter and activates its expression, TAp73-induced TRIM32 expression is efficiently repressed by DNp73. TRIM32 in turn physically interacts with TAp73 and promotes its ubiquitination and degradation, impairing p73-dependent transcriptional activity. This mutual regulation between p73 and TRIM32 constitutes a novel feedback loop, which might have important implications in central nervous system development as well as relevance in oncogenesis, and thus emerges as a possible therapeutic target.
Research center :
- Luxembourg Centre for Systems Biomedicine (LCSB): Developmental and Cellular Biology (Schwamborn Group)
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Gonzalez-Cano, L.
Hillje, Anna-Lena 
Fuertes-Alvarez, S.
Marques, M. M.
Blanch, A.
Ian, R. W.
Irwin, M. S.
Schwamborn, Jens Christian ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Marin, M. C.
External co-authors :
yes
Language :
English
Title :
Regulatory feedback loop between TP73 and TRIM32.
Publication date :
2013
Journal title :
Cell Death and Disease
ISSN :
2041-4889
Publisher :
Nature Publishing Group, London, United Kingdom
Volume :
4
Pages :
e704
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 07 July 2013

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