Reference : Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and s...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review.
Mandenius, Carl-Fredrik [> >]
Steel, Daniella [> >]
Noor, Fozia mailto [Saarland University > Biochemical Engineering]
Meyer, Thomas [> >]
Heinzle, Elmar [> >]
Asp, Julia [> >]
Arain, Sarina [> >]
Kraushaar, Udo [> >]
Bremer, Susanne [> >]
Class, Reiner [> >]
Sartipy, Peter [> >]
Journal of applied toxicology : JAT
Yes (verified by ORBilu)
[en] Animal Testing Alternatives ; Animals ; Cell Differentiation ; Cell Line, Transformed ; Drug Evaluation, Preclinical ; Drug-Related Side Effects and Adverse Reactions/classification ; Heart Diseases/chemically induced/pathology/physiopathology ; Humans ; Myocytes, Cardiac/drug effects/metabolism/pathology ; Oxygen Consumption ; Pluripotent Stem Cells/cytology/drug effects ; Xenobiotics/toxicity
[en] In this article, recent progress in cardiotoxicity testing based on the use of immortalized cell lines or human embryonic stem cell (hESC) derived cardiomyocytes in combination with state-of-the-art bioanalytical methods and sensors is reviewed. The focus is on hESC-derived cells and their refinement into competent testing cells, but the access and utility of other relevant cell types are also discussed. Recent developments in sensor techniques and bioanalytical approaches for measuring critical cardiotoxicity parameters are highlighted, together with aspects of data evaluation and validation. Finally, recommendations for further research are given.
Copyright (c) 2011 John Wiley & Sons, Ltd.

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