Article (Scientific journals)
The role of cognitive reappraisal in placebo analgesia: an fMRI study
Van Der Meulen, Marian; Kamping, Sandra; Anton, Fernand
2017In Social Cognitive and Affective Neuroscience, (2017), p. 1-10
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Abstract :
[en] Placebo analgesia (PA) depends crucially on the prefrontal cortex (PFC), which is assumed to be responsible for initiating the analgesic response. Surprisingly little research has focused on the psychological mechanisms mediated by the PFC and underlying PA. One increasingly accepted theory is that cognitive reappraisal—the reinterpretation of the meaning of adverse events—plays an important role, but no study has yet addressed the possible functional relationship with PA. We studied the influence of individual differences in reappraisal ability on PA and its prefrontal mediation. Participants completed a cognitive reappraisal ability task, which compared negative affect evoked by pictures in a reappraise versus a control condition. In a subsequent fMRI session, PA was induced using thermal noxious stimuli and an inert skin cream. We found a region in the left dorsolateral PFC, which showed a positive correlation between placebo-induced activation and (i) the reduction in participants’ pain intensity ratings; and (ii) cognitive reappraisal ability scores. Moreover, this region showed increased placebo-induced functional connectivity with the periaqueductal grey, indicating its involvement in descending nociceptive control. These initial findings thus suggest that cognitive reappraisal mechanisms mediated by the dorsolateral PFC may play a role in initiating pain inhibition in PA
Disciplines :
Neurosciences & behavior
Author, co-author :
Van Der Meulen, Marian  ;  University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Integrative Research Unit: Social and Individual Development (INSIDE)
Kamping, Sandra
Anton, Fernand ;  University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Integrative Research Unit: Social and Individual Development (INSIDE)
External co-authors :
yes
Language :
English
Title :
The role of cognitive reappraisal in placebo analgesia: an fMRI study
Publication date :
April 2017
Journal title :
Social Cognitive and Affective Neuroscience
ISSN :
1749-5024
Publisher :
Oxford University Press, Oxford, United Kingdom
Issue :
2017
Pages :
1-10
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 07 June 2017

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