Article (Scientific journals)
Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies
Baig, Komal; Ullmann, Pit; Haan, Serge et al.
2017In Molecular Cancer
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Keywords :
colorectal cancer; tumor-initiating cells; cancer stem cells; Culturing conditions; surface markers; Spheroid Culture System; metabolic identity; targeted therapy; inter- and intratumor heterogeneity
Abstract :
[en] Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self-renewal and tumorigenic properties as well as their resistance to conventional therapies. Despite significant advances in TIC biology, their isolation and identification remain largely disputed and incompletely established. In this review, we discuss the latest developments in isolation and culturing approaches of TICs, with focus on colorectal cancer (CRC). We feature recent findings on TIC-relevant signaling pathways and the metabolic identity of TICs, as well as their current clinical implications. Lastly, we highlight the influence of inter- and intra-tumoral heterogeneity on TIC function and targeting approaches.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Baig, Komal ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Ullmann, Pit ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Haan, Serge ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Letellier, Elisabeth ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
External co-authors :
no
Language :
English
Title :
Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies
Publication date :
16 February 2017
Journal title :
Molecular Cancer
ISSN :
1476-4598
Publisher :
BioMed Central, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Fondation Cancer
Fondation du Pélican de Mie
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