Reference : Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges ...

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/10993/30677

Title :	Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies
Language :	English
Author, co-author :	Baig, Komal [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
	Ullmann, Pit [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
	Haan, Serge [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
	Letellier, Elisabeth [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Publication date :	16-Feb-2017
Journal title :	Molecular Cancer
Peer reviewed :	Yes
e-ISSN :	1476-4598
Keywords :	[en] colorectal cancer ; tumor-initiating cells ; cancer stem cells ; Culturing conditions ; surface markers ; Spheroid Culture System ; metabolic identity ; targeted therapy ; inter- and intratumor heterogeneity
Abstract :	[en] Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self-renewal and tumorigenic properties as well as their resistance to conventional therapies. Despite significant advances in TIC biology, their isolation and identification remain largely disputed and incompletely established. In this review, we discuss the latest developments in isolation and culturing approaches of TICs, with focus on colorectal cancer (CRC). We feature recent findings on TIC-relevant signaling pathways and the metabolic identity of TICs, as well as their current clinical implications. Lastly, we highlight the influence of inter- and intra-tumoral heterogeneity on TIC function and targeting approaches.
Funders :	Fondation Cancer ; Fondation du Pélican de Mie
Target :	Researchers
Permalink :	http://hdl.handle.net/10993/30677
DOI :	10.1186/s12943-017-0602-2
FnR project :	FnR

	File(s) associated to this reference
	Fulltext file(s): File Commentary Version Size Access Open access Qureshi-Baig et al. 2017 Molecular Cancer.pdf Publisher postprint 1.19 MB View/Open

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