The potential interest of topiramate in addictions

Thorens, G.; Billieux, Joël; Manghi, R.; Khan, R.; Khazaal, Y.; Zullino, D. F.

doi:10.2174/138161211796150864

Reference : The potential interest of topiramate in addictions


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology
	To cite this reference:	http://hdl.handle.net/10993/29791

Title :	The potential interest of topiramate in addictions
Language :	-
Author, co-author :	Thorens, G. [Division of Addictology, University Hospitals of Geneva, Sweden]
	Billieux, Joël [University of Luxembourg > Faculty of Language and Literature, Humanities, Arts and Education (FLSHASE) > Integrative Research Unit: Social and Individual Development (INSIDE)]
	Manghi, R. [Division of Addictology, University Hospitals of Geneva, Sweden]
	Khan, R. [Division of Addictology, University Hospitals of Geneva, Sweden]
	Khazaal, Y. [Division of Addictology, University Hospitals of Geneva, Sweden]
	Zullino, D. F. [Division of Addictology, University Hospitals of Geneva, Sweden]
Publication date :	2011
Journal title :	Current Pharmaceutical Design
Volume :	17
Issue/season :	14
Pages :	1410-1415
Peer reviewed :	Yes (verified by ORBi^lu)
Audience :	International
ISSN :	13816128
Keywords :	[en] Addictions ; Drug abuse ; Topiramate ; Treatment ; AMPA receptor ; Behavior, Addictive ; Drug Delivery Systems ; Fructose ; Glutamic Acid ; Humans ; Models, Biological ; Neuroprotective Agents ; Receptors, AMPA ; Recurrence ; Substance-Related Disorders
Abstract :	[en] Topiramate is one of the currently most promising compounds in the field of addiction medicine. This paper discusses its potential utility related to a phase model of addiction development, focusing on the assumption that addiction is a continuous process involving different neurobiological pathways, depending on the stage of addiction. A specific emphasis will be made on the development of dysfunctional automatic behaviors in the late stage of addiction and the central role of glutamate and AMPA receptors. The aim is to propose that if too broad an effect of anti-addiction medication is expected (such as anti-craving, anti-relapse and preventive effects), the results might be disappointing. The speculative specific efficacy of topiramate in addiction is described. ©2011 Bentham Science Publishers Ltd.
Permalink :	http://hdl.handle.net/10993/29791
DOI :	10.2174/138161211796150864

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