Article (Scientific journals)
GTPases and the control of neuronal polarity.
Schwamborn, Jens Christian; Li, Yinghua; Puschel, Andreas W.
2006In Methods in Enzymology, 406, p. 715-27
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Keywords :
Animals; Base Sequence; Cell Differentiation/physiology; Cell Polarity/drug effects/physiology; Cells, Cultured; GTP Phosphohydrolases/genetics/physiology; Hippocampus/cytology; Molecular Sequence Data; Neurons/physiology; RNA Interference; Rats; Transfection; cdc42 GTP-Binding Protein/metabolism
Abstract :
[en] Neurons are probably the most highly polarized cell type and typically develop a single axon and several dendrites. The establishment of a polarized morphology and the functional specialization of axonal and dendritic compartments are essential steps in the differentiation of neurons. Primary cultures of dissociated hippocampal neurons are a widely used system to study the development of neuronal differentiation. In this article, we will describe gain-of-function and loss-of-function approaches that allow us to analyze the role of GTPases in neuronal differentiation.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Schwamborn, Jens Christian ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Li, Yinghua
Puschel, Andreas W.
Language :
English
Title :
GTPases and the control of neuronal polarity.
Publication date :
2006
Journal title :
Methods in Enzymology
ISSN :
0076-6879
Publisher :
Elsevier, United States
Volume :
406
Pages :
715-27
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBilu :
since 21 June 2013

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