Reference : GTPases and the control of neuronal polarity.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
GTPases and the control of neuronal polarity.
Schwamborn, Jens Christian mailto [University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit >]
Li, Yinghua [> >]
Puschel, Andreas W. [> >]
Methods in Enzymology
Yes (verified by ORBilu)
United States
[en] Animals ; Base Sequence ; Cell Differentiation/physiology ; Cell Polarity/drug effects/physiology ; Cells, Cultured ; GTP Phosphohydrolases/genetics/physiology ; Hippocampus/cytology ; Molecular Sequence Data ; Neurons/physiology ; RNA Interference ; Rats ; Transfection ; cdc42 GTP-Binding Protein/metabolism
[en] Neurons are probably the most highly polarized cell type and typically develop a single axon and several dendrites. The establishment of a polarized morphology and the functional specialization of axonal and dendritic compartments are essential steps in the differentiation of neurons. Primary cultures of dissociated hippocampal neurons are a widely used system to study the development of neuronal differentiation. In this article, we will describe gain-of-function and loss-of-function approaches that allow us to analyze the role of GTPases in neuronal differentiation.

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