Article (Scientific journals)
The E3-ubiquitin ligase TRIM2 regulates neuronal polarization.
Khazaei, Mohammad R.; Bunk, Eva C.; Hillje, Anna-Lena et al.
2011In Journal of Neurochemistry, 117 (1), p. 29-37
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Keywords :
Animals; Axons/enzymology/physiology; Cell Polarity/physiology; Cells, Cultured; HEK293 Cells; Hippocampus/cytology/enzymology/physiology; Humans; Mice; Neurogenesis/physiology; Neurons/cytology/enzymology/physiology; Proteins/antagonists & inhibitors/physiology; Ubiquitin-Protein Ligases/physiology
Abstract :
[en] The establishment of a polarized morphology with a single axon and multiple dendrites is an essential step during neuronal differentiation. This cellular polarization is largely depending on changes in the dynamics of the neuronal cytoskeleton. Here, we show that the tripartite motif (TRIM)-NHL protein TRIM2 is regulating axon specification in cultured mouse hippocampal neurons, where one of several initially indistinguishable neurites is selected to become the axon. Suppression of TRIM2 by RNA interference results in the loss of neuronal polarity while over-expression of TRIM2 induces the specification of multiple axons. TRIM2 conducts its function during neuronal polarization by ubiquitination of the neurofilament light chain. Together, our results imply an important function of TRIM2 for axon outgrowth during development.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Khazaei, Mohammad R.
Bunk, Eva C.
Hillje, Anna-Lena
Jahn, Hannah M.
Riegler, Eva M.
Knoblich, Jurgen A.
Young, Peter
Schwamborn, Jens Christian ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Language :
English
Title :
The E3-ubiquitin ligase TRIM2 regulates neuronal polarization.
Publication date :
2011
Journal title :
Journal of Neurochemistry
ISSN :
1471-4159
Publisher :
Blackwell, Oxford, United Kingdom
Volume :
117
Issue :
1
Pages :
29-37
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) 2010 The Authors. Journal of Neurochemistry (c) 2010 International Society for Neurochemistry.
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