Article (Scientific journals)
Neural stem cells maintain their stemness through protein kinase C zeta-mediated inhibition of TRIM32.
Hillje, Anna-Lena; Worlitzer, Maik M. A.; Palm, Thomas et al.
2011In Stem Cells, 29 (9), p. 1437-47
Peer Reviewed verified by ORBi
 

Files


Full Text
2011_Hillje.pdf
Publisher postprint (670.97 kB)
Request a copy

All documents in ORBilu are protected by a user license.

Send to



Details



Keywords :
Animals; Cell Differentiation/physiology; Cell Growth Processes/physiology; Down-Regulation; Immunohistochemistry; Mice; Neural Stem Cells/cytology/enzymology; Protein Kinase C/metabolism; Stem Cells/cytology/enzymology; Transfection; Ubiquitin-Protein Ligases/antagonists & inhibitors/genetics/metabolism
Abstract :
[en] Several studies over the last couple of years have delivered insights into the mechanisms that drive neuronal differentiation. However, the mechanisms that ensure the maintenance of stemness characteristics in neural stem cells over several rounds of cell divisions are still largely unknown. Here, we provide evidence that the neuronal fate determinant TRIM32 binds to the protein kinase C zeta. Through this interaction, TRIM32 is retained in the cytoplasm. However, during differentiation, this interaction is abrogated and TRIM32 translocates to the nucleus to initiate neuronal differentiation by targeting c-Myc for proteasomal degradation.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Hillje, Anna-Lena
Worlitzer, Maik M. A.
Palm, Thomas
Schwamborn, Jens Christian ;  University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Language :
English
Title :
Neural stem cells maintain their stemness through protein kinase C zeta-mediated inhibition of TRIM32.
Publication date :
2011
Journal title :
Stem Cells
ISSN :
1549-4918
Publisher :
Wiley, Malden, United States - Massachusetts
Volume :
29
Issue :
9
Pages :
1437-47
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2011 AlphaMed Press.
Available on ORBilu :
since 21 June 2013

Statistics


Number of views
93 (4 by Unilu)
Number of downloads
0 (0 by Unilu)

Scopus citations®
 
43
Scopus citations®
without self-citations
23
OpenCitations
 
37
WoS citations
 
43

Bibliography


Similar publications



Contact ORBilu