[en] Several studies over the last couple of years have delivered insights into the mechanisms that drive neuronal differentiation. However, the mechanisms that ensure the maintenance of stemness characteristics in neural stem cells over several rounds of cell divisions are still largely unknown. Here, we provide evidence that the neuronal fate determinant TRIM32 binds to the protein kinase C zeta. Through this interaction, TRIM32 is retained in the cytoplasm. However, during differentiation, this interaction is abrogated and TRIM32 translocates to the nucleus to initiate neuronal differentiation by targeting c-Myc for proteasomal degradation.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Hillje, Anna-Lena
Worlitzer, Maik M. A.
Palm, Thomas
Schwamborn, Jens Christian ; University of Luxembourg > Faculty of Science, Technology and Communication (FSTC) > Life Science Research Unit
Language :
English
Title :
Neural stem cells maintain their stemness through protein kinase C zeta-mediated inhibition of TRIM32.