| Proinsulin, GLP-1, and glucagon are associated with partial remission in children and adolescents with newly diagnosed type 1 diabetes |
| English |
| Kaas, A. [Department of Paediatrics, Glostrup/Herlev University Hospital, Copenhagen, Denmark] |
| Max Andersen, M. L. [Department of Paediatrics, Glostrup/Herlev University Hospital, Copenhagen, Denmark] |
| Fredheim, S. [Department of Paediatrics, Glostrup/Herlev University Hospital, Copenhagen, Denmark] |
| Hougaard, P. [Department of Statistics, University of Southern Denmark, Odense, Denmark] |
| Buschard, K. [Bartholin Institute, Rigshospitalet, Copenhagen, Denmark] |
| Petersen, J. S. [Diabetes Biology and Pharmacology, Novo Nordisk A/S, Måløv, Denmark] |
| De Beaufort, Carine  [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >] |
| Robertson, K. J. [Department of Paediatrics, Royal Hospital for Sick Children, Yorkhill, Glasgow, Scotland, United Kingdom] |
| Hansen, L. [Department of Paediatrics, Glostrup/Herlev University Hospital, Copenhagen, Denmark] |
| Mortensen, H. B. [Department of Paediatrics, Glostrup/Herlev University Hospital, Copenhagen, Denmark] |
| Nielsen, L. B. [Department of Paediatrics, Glostrup/Herlev University Hospital, Copenhagen, Denmark] |
| Aanstoot, H.-J. [Erasmus University Medical Centre, Rotterdam, Netherlands] |
| De Beaufort, Carine [University of Luxembourg > Luxembourg Centre for Systems Biomedicine (LCSB) >] |
| Chiarelli, F. [Clinica Pediatrica, Chieti, Italy] |
| Dahl-Jørgensen, K. [Ullevål University Hospital, Department of Paediatrics, Oslo, Norway] |
| Göthner, H. B. [Ullevål University Hospital, Department of Paediatrics, Oslo, Norway] |
| Danne, T. [Charité, Campus Virchow-Klinikum, Berlin, Germany] |
| Garandeau, P. [Unité D'endocrinologie Diabetologie Infantile, Institut Saint Pierre, France] |
| Greene, S. A. [University of Dundee, Scotland, United Kingdom] |
| Holl, R. W. [University of Ulm, Germany] |
| Kocova, M. [Pediatric Clinic-Skopje, Macedonia] |
| Martul, P. [Endocrinologia Pediatrica Hospital De Cruces, Spain] |
| Matsuura, N. [Kitasato University School of Medicine, Japan] |
| Mortensen, H. B. [Department of Pediatrics, Glostrup University Hospital, Denmark] |
| Robertson, K. J. [Royal Hospital for Sick Children, Yorkhill, Glasgow, Scotland, United Kingdom] |
| Schoenle, E. J. [University Children's Hospital, Zurich, Switzerland] |
| Swift, P. [Leicester Royal Infirmary Childrens Hospital, Leicester, United Kingdom] |
| Tsou, R. M. [Paediatric Department Oporto, Portugal] |
| Vanelli, M. [Paediatrics, University of Parma, Italy] |
| Åman, J. [Örebro Medical Centre Hospital, Department of Paediatrics, Sweden] |
| Feb-2012 |
| Pediatric Diabetes |
| 13 |
| 1 |
| 51-58 |
| Yes |
| 1399543X |
| [en] GLP-1 ; Glucagon ; Proinsulin ; Remission phase ; Type 1 diabetes ; C peptide ; Adolescent ; Age of Onset ; Blood Glucose ; C-Peptide ; Child ; Child, Preschool ; Cohort Studies ; Diabetes Mellitus, Type 1 ; Female ; Follow-Up Studies ; Glucagon-Like Peptide 1 ; Humans ; Infant ; Infant, Newborn ; Male ; Remission, Spontaneous |
| [en] Objective: Proinsulin is a marker of beta-cell distress and dysfunction in type 2 diabetes and transplanted islets. Proinsulin levels are elevated in patients newly diagnosed with type 1 diabetes. Our aim was to assess the relationship between proinsulin, insulin dose-adjusted haemoglobin A1c (IDAA1C), glucagon-like peptide-1 (GLP-1), glucagon, and remission status the first year after diagnosis of type 1 diabetes. Methods: Juvenile patients (n = 275) were followed 1, 6, and 12 months after diagnosis. At each visit, partial remission was defined as IDAA1C ≤9%. The patients had a liquid meal test at the 1-, 6-, and 12-month visits, which included measurement of C-peptide, proinsulin, GLP-1, glucagon, and insulin antibodies (IA). Results: Patients in remission at 6 and 12 months had significantly higher levels of proinsulin compared to non-remitting patients (p < 0.0001, p = 0.0002). An inverse association between proinsulin and IDAA1C was found at 1 and 6 months (p = 0.0008, p = 0.0022). Proinsulin was positively associated with C-peptide (p < 0.0001) and IA (p = 0.0024, p = 0.0068, p < 0.0001) at 1, 6, and 12 months. Glucagon (p < 0.0001 and p < 0.02) as well as GLP-1 (p = 0.0001 and p = 0.002) were significantly lower in remitters than in non-remitters at 6 and 12 months. Proinsulin associated positively with GLP-1 at 1 month (p = 0.004) and negatively at 6 (p = 0.002) and 12 months (p = 0.0002). Conclusions: In type 1 diabetes, patients in partial remission have higher levels of proinsulin together with lower levels of GLP-1 and glucagon compared to patients not in remission. In new onset type 1 diabetes proinsulin level may be a sign of better residual beta-cell function. © 2011 John Wiley & Sons A/S. |
| http://hdl.handle.net/10993/26979 |
| 10.1111/j.1399-5448.2011.00812.x |
