Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

Legrand, Nicolas; Ploss, Alexander; Balling, Rudi; Becker, Pablo D.; Borsotti, Chiara; Brezillon, Nicolas; Debarry, Jennifer; de Jong, Ype; Deng, Hongkui; Di Santo, James P.; Eisenbarth, Stephanie; Eynon, Elizabeth; Flavell, Richard A.; Guzman, Carlos A.; Huntington, Nicholas D.; Kremsdorf, Dina; Manns, Michael P.; Manz, Markus G.; Mention, Jean-Jacques; Ott, Michael; Rathinam, Chozhavendan; Rice, Charles M.; Rongvaux, Anthony; Stevens, Sean; Spits, Hergen; Strick-Marchand, Helene; Takizawa, Hitoshi; van Lent, Anja U.; Wang, Chengyan; Weijer, Kees; Willinger, Tim; Ziegler, Patrick

Reference : Humanized mice for modeling human infectious disease: challenges, progress, and outlook.


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Genetics & genetic processes
	To cite this reference:	http://hdl.handle.net/10993/2686

Title :	Humanized mice for modeling human infectious disease: challenges, progress, and outlook.
Language :	English
Author, co-author :	Legrand, Nicolas [> >]
	Ploss, Alexander [> >]
	Balling, Rudi []
	Becker, Pablo D. [> >]
	Borsotti, Chiara [> >]
	Brezillon, Nicolas [> >]
	Debarry, Jennifer [> >]
	de Jong, Ype [> >]
	Deng, Hongkui [> >]
	Di Santo, James P. [> >]
	Eisenbarth, Stephanie [> >]
	Eynon, Elizabeth [> >]
	Flavell, Richard A. [> >]
	Guzman, Carlos A. [> >]
	Huntington, Nicholas D. [> >]
	Kremsdorf, Dina [> >]
	Manns, Michael P. [> >]
	Manz, Markus G. [> >]
	Mention, Jean-Jacques [> >]
	Ott, Michael [> >]
	Rathinam, Chozhavendan [> >]
	Rice, Charles M. [> >]
	Rongvaux, Anthony [> >]
	Stevens, Sean [> >]
	Spits, Hergen [> >]
	Strick-Marchand, Helene [> >]
	Takizawa, Hitoshi [> >]
	van Lent, Anja U. [> >]
	Wang, Chengyan [> >]
	Weijer, Kees [> >]
	Willinger, Tim [> >]
	Ziegler, Patrick [> >]
Publication date :	2009
Journal title :	Cell Host & Microbe
Volume :	6
Issue/season :	1
Pages :	5-9
Peer reviewed :	Yes
ISSN :	1931-3128
e-ISSN :	1934-6069
Country :	United States
Keywords :	[en] Animals ; Biomedical Research/trends ; Communicable Diseases ; Disease Models, Animal ; Humans ; Mice
Abstract :	[en] Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.
Permalink :	http://hdl.handle.net/10993/2686

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